Abstract
Objective: This study aimed to investigate the maternal–neonatal outcomes of twin pregnancies of mothers with preeclampsia and their association with assisted reproductive technology (ART). Methods: A retrospective study on the clinical and maternal–neonatal outcome data of 698 women with twin pregnancies who delivered in our hospital from December 2013 to September 2021 was conducted. Continuous variables were analyzed using a Student’s t-test or Wilcoxon rank-sum test. Categorical variables were analyzed using the Chi-square test. The risk factors of twin pregnancies with preeclampsia were analyzed by logistic regression. Results: The rate of twin pregnancy complicated by preeclampsia was 17.62% (123/698). Logistic regression analysis showed that ART increased the risk of preeclampsia in twin pregnancies (AOR: 1.868, 95% CI: 1.187–2.941). Mothers with preeclampsia carrying twins conceived with ART had a higher rate of delivery at gestational week < 34 (29.9% vs. 12.5%) and asphyxia of the neonate at 5 min after delivery (13.4% vs. 1.8%) than those with preeclampsia conceived without ART (p < 0.05). Conclusions: ART increases the risk of preeclampsia in twin pregnancies and the rate of adverse maternal–neonatal outcomes for twin pregnancies with preeclampsia. The policy of single embryo transfer is a method to reduce the adverse pregnancy outcomes of ART.
Funder
Tianjin Municipal Science and Technology Commission Special Foundation for Science and Technology Major Projects in Control and Prevention of Major Diseases
National Natural Science Foundation of China
Reference44 articles.
1. Births: Preliminary Data for 2014. National vital statistics reports: From the Centers for Disease Control and Prevention, National Center for Health Statistics;Hamilton;Natl. Vital Stat. Syst.,2015
2. Three decades of twin births in the United States, 1980–2009;Martin;NCHS Data Brief,2012
3. Systematic review of worldwide trends in assisted reproductive technology 2004–2013
4. Neonatal and maternal outcomes among twin pregnancies stratified by mode of conception in the United States
5. Obstetric outcomes for twins from different conception methods – A multicenter cross‐sectional study from China
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