Functional Recovery and Regenerative Effects of Direct Transcutaneous Electrical Nerve Stimulation in Treatment of Post-COVID-19 Guillain–Barré and Acute Transverse Myelitis Overlap Syndrome: A Clinical Case

Author:

Al-Zamil Mustafa12ORCID,Kulikova Natalia G.13,Minenko Inessa A.23,Mansur Numman124,Zalozhnev Denis M.2,Uzdenov Marat B.5,Dzhanibekova Alina A.5ORCID,Gochiyayev Alikhan A.5,Shnayder Natalia A.67ORCID

Affiliation:

1. Department of Physiotherapy, Faculty of Continuing Medical Education, Peoples’ Friendship University of Russia, 117198 Moscow, Russia

2. Department of Restorative Medicine and Neurorehabilitation, Medical Dental Institute, 127253 Moscow, Russia

3. Department of Sports Medicine and Medical Rehabilitation, I.M. Sechenov First Moscow State Medical University, 119991 Moscow, Russia

4. City Clinical Hospital Named after V. V. Vinogradov, 117292 Moscow, Russia

5. Medical Institute, North Caucasian State Academy, 369001 Cherkessk, Russia

6. Institute of Personalized Psychiatry and Neurology, V.M. Bekhterev National Medical Research Centre for Psychiatry and Neurology, 192019 Saint Petersburg, Russia

7. Shared Core Facilities “Molecular and Cell Technologies”, Professor V. F. Voino-Yasenetsky Krasnoyarsk State Medical University, 660022 Krasnoyarsk, Russia

Abstract

Transcutaneous electrical nerve stimulation (TENS) has proven effective in treating pain in many experimental and clinical studies. In addition to the analgesic effect, direct TENS of peripheral nerves had anti-inflammatory and regenerative effects in the treatment of distal polyneuropathy and spinal cord injury. This work demonstrates the experience of using direct TENS in the treatment of a 52-year-old patient with post-COVID-19 Guillain–Barré (GBS) and acute transverse myelitis (ATM) overlap syndrome. Direct TENS of peripheral nerves showed high efficiency in enhancing the therapeutic effect of combined plasma exchange and pharmacotherapy by 89.5% with a significant reduction in neuropathic pain, motor and sensory deficits, bladder and bowel disorders and regression of neurophysiological changes. We suggest that direct TENS of peripheral nerves can be a promising option for combined therapy of GBS and ATM overlap syndrome and other diseases with the simultaneous development of distal polyneuropathy and spinal cord injury. Further trial studies are required.

Publisher

MDPI AG

Reference50 articles.

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2. Acute Transverse Myelitis (ATM):Clinical Review of 43 Patients with COVID-19-Associated ATM and 3 Post-Vaccination ATM Serious Adverse Events with the ChAdOx1 nCoV-19 Vaccine (AZD1222);Gracia;Front. Immunol.,2021

3. Simone, C.G., and Emmady, P.D. (2023). StatPearls [Internet], StatPearls Publishing.

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