A Flexible Optoelectronic Device for Continuous Cerebral Blood Flow Monitoring

Abstract

Human cerebral oxygenation and hemodynamics can be estimated by cerebral oxygenation parameters. Functional near-infrared spectroscopy (fNIRS) can be used to measure the hemoglobin concentration index of brain tissue noninvasively and in real time. However, limited by cumbersome equipment, high price and uncomfortable wear, conventional fNIRS monitoring systems still cannot achieve continuous and long-term monitoring. In this work, a flexible and wearable long-term monitoring system is developed featured with cost efficiency, simple preparation and light weight (only 1.6 g), which consists of a pair of light-emitting diodes (LEDs) and a photodetector (PD). Triangular serpentine interconnectors are introduced to connect the functional elements, enabling the device to be stretched in multiple directions. The device can continuously work for 7 h and be subjected to 2000 cycles of bending loading, with less than 3% change in voltage value, 1.89% and 1.9% change in LED luminous power and 0.9% change in voltage value. Furthermore, the hand-gripping and breath-holding experiments show that the system can accurately measure the changes in hemoglobin concentration in accordance with the commercial device. The flexible fNIRS system presented here not only provides a simple preparation process but also offers new ideas for daily cerebral state monitoring and prolonged clinical monitoring.