Numerical Simulations of Combined Dielectrophoresis and Alternating Current Electrothermal Flow for High-Efficient Separation of (Bio)Microparticles
-
Published:2024-02-29
Issue:3
Volume:15
Page:345
-
ISSN:2072-666X
-
Container-title:Micromachines
-
language:en
-
Short-container-title:Micromachines
Author:
Jiang Hao1, Li Yalin1, Du Fei2, Nie Zhaoguang1, Wei Gang1ORCID, Wang Yan1ORCID, Liu Xiaomin1
Affiliation:
1. College of Chemistry and Chemical Engineering, Qingdao University, Qingdao 266071, China 2. Institute of Water Chemistry, Technische Universität Dresden, D 01062 Dresden, Germany
Abstract
High-efficient separation of (bio)microparticles has important applications in chemical analysis, environmental monitoring, drug screening, and disease diagnosis and treatment. As a label-free and high-precision separation scheme, dielectrophoresis (DEP) has become a research hotspot in microparticle separation, especially for biological cells. When processing cells with DEP, relatively high electric conductivities of suspending media are sometimes required to maintain the biological activities of the biosample, which results in high temperature rises within the system caused by Joule heating. The induced temperature gradient generates a localized alternating current electrothermal (ACET) flow disturbance, which seriously impacts the DEP manipulation of cells. Based on this, we propose a novel design of the (bio)microparticle separator by combining DEP with ACET flow to intensify the separation process. A coupling model that incorporates electric, fluid flow, and temperature fields as well as particle tracking is established to predict (bio)microparticle trajectories within the separator. Numerical simulations reveal that both ACET flow and DEP motion act in the same plane but in different directions to achieve high-precision separation between particles. This work provides new design ideas for solving the very tricky Joule heating interference in the DEP separation process, which paves the way for further improving the throughput of the DEP-based (bio)microparticle separation system.
Funder
National Natural Science Foundation of China Natural Science Foundation of Shandong Province Taishan Scholars Program of Shandong Province China Postdoctoral Science Foundation
Reference27 articles.
1. Hata, M., Suzuki, M., and Yasukawa, T. (2022). Selective retrieval of antibody-secreting hybridomas in cell arrays based on the dielectrophoresis. Biosens. Bioelectron., 209. 2. Piezoelectricity induced by pulsed hydraulic pressure enables in situ membrane demulsification and oil/water separation;Zhao;Water Res.,2022 3. Fabrication of a new all-in-one microfluidic dielectrophoresis integrated chip and living cell separation;Oshiro;Iscience,2022 4. Muhsin, S.A., Al-Amidie, M., Shen, Z., Mlaji, Z., Liu, J., Abdullah, A., El-Dweik, M., Zhang, S., and Almasri, M. (2022). A microfluidic biosensor for rapid simultaneous detection of waterborne pathogens. Biosens. Bioelectron., 203. 5. Russo, G.I., Musso, N., Romano, A., Caruso, G., Petralia, S., Lanzano, L., Broggi, G., and Camarda, M. (2022). The Role of Dielectrophoresis for Cancer Diagnosis and Prognosis. Cancers, 14.
Cited by
1 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献
|
|