Reactions of Polychlorinated Pyrimidines with DABCO-Reference-Cited by-同舟云学术

Reactions of Polychlorinated Pyrimidines with DABCO

Published:2019-10-14 Issue:4 Volume:2019 Page:M1084
ISSN:1422-8599
Container-title:Molbank
language:en
Short-container-title:Molbank

Author:

Kalogirou Andreas S.^ORCID,Koutentis Panayiotis A.^ORCID

Abstract

The reaction of 2,4,5,6-tetrachloropyrimidine (4) and 4,5,6-trichloropyrimidine-2-carbonitrile (1) with DABCO (1 equiv.), in MeCN, at ca. 20 °C gives 2,4,5-trichloro-6-[4-(2-chloroethyl)piperazin-1-yl]pyrimidine (5) and 4,5-dichloro-6-[4-(2-chloroethyl)piperazin-1-yl]pyrimidine-2-carbonitrile (6) in 42% and 52% yields, respectively. The new compounds were fully characterized.

Publisher

MDPI AG

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

https://www.mdpi.com/1422-8599/2019/4/M1084/pdf

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