Visualization of Metastatic Lung Cancer with TiNIR

Author:

Mun Seul-Ki12ORCID,Sim Hyun Bo1ORCID,Han Ji Yeon1,Kim Hyeongyeong1,Park Dae-Han1,Chang Dong-Jo2ORCID,Yee Sung-Tae2ORCID,Chang Young-Tae34ORCID,Kim Jong-Jin1ORCID

Affiliation:

1. Department of Biomedical Science, Sunchon National University, 255 Jungang-ro, Suncheon 57922, Republic of Korea

2. Department of Pharmacy, Sunchon National University, 255 Jungang-ro, Suncheon 57922, Republic of Korea

3. School of Interdisciplinary Bioscience and Bioengineering, Pohang University of Science and Technology (POSTECH), Pohang 37673, Republic of Korea

4. Department of Chemistry, Pohang University of Science and Technology (POSTECH), Pohang 37673, Republic of Korea

Abstract

The development of efficient biomarkers and probes for monitoring and treating cancer, specifically metastatic cancer, is a critical research area that can have a significant impact on both patient outcomes and drug discovery. In this context, TiNIR has been developed to detect tumor-initiating cells (TICs), with heme oxygenase 2 (HO2) as a promising therapeutic biomarker for tumor-initiating cells. In this study, TiNIR has demonstrated its effectiveness as an in vivo metastatic lung cancer tracker, highlighting its potential as a valuable tool in cancer research and therapy. The development of innovative approaches that selectively target metastatic cancers represents a promising avenue for improving survival rates and enhancing the quality of life of cancer patients.

Funder

Sunchon National University

National Research Foundation of Korea

Basic Science Research Institute Fund

Publisher

MDPI AG

Subject

Radiology, Nuclear Medicine and imaging

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