Natural Bioactive Products as Epigenetic Modulators for Treating Neurodegenerative Disorders

Author:

Martínez-Iglesias Olaia1,Naidoo Vinogran1,Carrera Iván1,Corzo Lola1,Cacabelos Ramón1ORCID

Affiliation:

1. EuroEspes Biomedical Research Center, International Center of Neuroscience and Genomic Medicine, 15165 Bergondo, Corunna, Spain

Abstract

Neurodegenerative disorders (NDDs) are major health issues in Western countries. Despite significant efforts, no effective therapeutics for NDDs exist. Several drugs that target epigenetic mechanisms (epidrugs) have been recently developed for the treatment of NDDs, and several of these are currently being tested in clinical trials. Furthermore, various bioproducts have shown important biological effects for the potential prevention and treatment of these disorders. Here, we review the use of natural products as epidrugs to treat NDDs in order to explore the epigenetic effects and benefits of functional foods and natural bioproducts on neurodegeneration.

Publisher

MDPI AG

Subject

Drug Discovery,Pharmaceutical Science,Molecular Medicine

Reference215 articles.

1. Alzheimer’s Association (2020). 2020 Alzheimer’s disease facts and figures. Alzheimers Dement., 16, 391–460.

2. GDB (2022). 2019 Dementia Forecasting Collaborators. Estimation of the global prevalence of dementia in 2019 and forecasted prevalence in 2050: An analysis for the Global Burden of Disease Study. Lancet Public Health, 7, e105–e125.

3. Can cloud-based tools accelerate Alzheimer’s disease drug discovery?;Cacabelos;Expert Opin. Drug. Discov.,2016

4. Pharmacogenomics of Alzheimer’s and Parkinson’s Diseases;Cacabelos;Neurosci. Lett.,2018

5. Molecular genetics of Alzheimer’s disease and ageing;Cacabelos;Methods Find Exp. Clin. Pharm.,2005

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