Abstract
Epilepsy is a long-term neurological condition that results in recurrent seizures. Approximately 30% of patients with epilepsy have drug-resistant epilepsy (DRE). The ketogenic diet (KD) is considered an effective alternative treatment for epileptic patients. The aim of this study was to identify the metabolic role of the KD in epilepsy. Ketone bodies induce chemical messengers and alterations in neuronal metabolic activities to regulate neuroprotective mechanisms towards oxidative damage to decrease seizure rate. Here, we discuss the role of KD on epilepsy and related metabolic disorders, focusing on its mechanism of action, favorable effects, and limitations. We describe the significant role of the KD in managing epilepsy disorders.
Subject
Food Science,Nutrition and Dietetics
Reference100 articles.
1. Verrotti, A., Iapadre, G., Di Francesco, L., Zagaroli, L., and Farello, G. (2020). Diet in the Treatment of Epilepsy: What We Know So Far. Nutrients, 12.
2. Epilepsy diagnosis based on one unprovoked seizure and ≥60% risk. A systematic review of the etiologies;López;Epilepsy Behav.,2021
3. Structural basis of epilepsy-related ligand–receptor complex LGI1–ADAM22;Yamagata;Nat. Commun.,2018
4. Management of the patient with medically refractory epilepsy;Granata;Expert. Rev. Neurother.,2009
5. Use of ketogenic diet therapy in infants with epilepsy: A systematic review and meta-analysis;Lyons;Epilepsia,2020
Cited by
9 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献