Cis-Regulatory Elements in Mammals
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Published:2023-12-26
Issue:1
Volume:25
Page:343
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ISSN:1422-0067
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Container-title:International Journal of Molecular Sciences
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language:en
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Short-container-title:IJMS
Author:
Liu Xingyu1,
Chen Mengjie1,
Qu Xiuwen1,
Liu Wenjing1,
Dou Yuting1,
Liu Qingyou1,
Shi Deshun1ORCID,
Jiang Mingsheng1,
Li Hui1ORCID
Affiliation:
1. State Key Laboratory for Conservation and Utilization of Subtropical Agro-Bioresources, Guangxi Key Laboratory of Animal Breeding, Disease Control and Prevention, College of Animal Science and Technology, Guangxi University, Nanning 530005, China
Abstract
In cis-regulatory elements, enhancers and promoters with complex molecular interactions are used to coordinate gene transcription through physical proximity and chemical modifications. These processes subsequently influence the phenotypic characteristics of an organism. An in-depth exploration of enhancers and promoters can substantially enhance our understanding of gene regulatory networks, shedding new light on mammalian development, evolution and disease pathways. In this review, we provide a comprehensive overview of the intrinsic structural attributes, detection methodologies as well as the operational mechanisms of enhancers and promoters, coupled with the relevant novel and innovative investigative techniques used to explore their actions. We further elucidated the state-of-the-art research on the roles of enhancers and promoters in the realms of mammalian development, evolution and disease, and we conclude with forward-looking insights into prospective research avenues.
Funder
National Natural Science Foundation of China
Guangxi Natural Science Foundation
State Key Laboratory for Conservation and Utilization of Subtropical Agro-Bioresources
Guangxi Distinguished Scholars Program
Guangxi Science and Technology Major Project
Subject
Inorganic Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Computer Science Applications,Spectroscopy,Molecular Biology,General Medicine,Catalysis
Cited by
1 articles.
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