The Healthy and Diseased Retina Seen through Neuron–Glia Interactions
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Published:2024-01-17
Issue:2
Volume:25
Page:1120
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ISSN:1422-0067
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Container-title:International Journal of Molecular Sciences
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language:en
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Short-container-title:IJMS
Author:
Tempone Matheus H.1ORCID, Borges-Martins Vladimir P.2ORCID, César Felipe1ORCID, Alexandrino-Mattos Dio Pablo1ORCID, de Figueiredo Camila S.3ORCID, Raony Ícaro4, dos Santos Aline Araujo2ORCID, Duarte-Silva Aline Teixeira3, Dias Mariana Santana5ORCID, Freitas Hércules Rezende4ORCID, de Araújo Elisabeth G.36ORCID, Ribeiro-Resende Victor Tulio1, Cossenza Marcelo2ORCID, P. Silva Hilda5ORCID, P. de Carvalho Roberto3ORCID, Ventura Ana L. M.3, Calaza Karin C.3ORCID, Silveira Mariana S.7ORCID, Kubrusly Regina C. C.2ORCID, de Melo Reis Ricardo A.1ORCID
Affiliation:
1. Laboratory of Neurochemistry, Institute of Biophysics Carlos Chagas Filho, Federal University of Rio de Janeiro, Rio de Janeiro 21949-000, Brazil 2. Department of Physiology and Pharmacology, Biomedical Institute and Program of Neurosciences, Federal Fluminense University, Niterói 24020-150, Brazil 3. Department of Neurobiology and Program of Neurosciences, Institute of Biology, Federal Fluminense University, Niterói 24020-141, Brazil 4. Institute of Medical Biochemistry Leopoldo de Meis, Federal University of Rio de Janeiro, Rio de Janeiro 21941-902, Brazil 5. Laboratory of Gene Therapy and Viral Vectors, Institute of Biophysics Carlos Chagas Filho, Federal University of Rio de Janeiro, Rio de Janeiro 21949-000, Brazil 6. National Institute of Science and Technology on Neuroimmunomodulation—INCT-NIM, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro 21040-360, Brazil 7. Laboratory for Investigation in Neuroregeneration and Development, Institute of Biophysics Carlos Chagas Filho, Federal University of Rio de Janeiro, Rio de Janeiro 21949-000, Brazil
Abstract
The retina is the sensory tissue responsible for the first stages of visual processing, with a conserved anatomy and functional architecture among vertebrates. To date, retinal eye diseases, such as diabetic retinopathy, age-related macular degeneration, retinitis pigmentosa, glaucoma, and others, affect nearly 170 million people worldwide, resulting in vision loss and blindness. To tackle retinal disorders, the developing retina has been explored as a versatile model to study intercellular signaling, as it presents a broad neurochemical repertoire that has been approached in the last decades in terms of signaling and diseases. Retina, dissociated and arranged as typical cultures, as mixed or neuron- and glia-enriched, and/or organized as neurospheres and/or as organoids, are valuable to understand both neuronal and glial compartments, which have contributed to revealing roles and mechanisms between transmitter systems as well as antioxidants, trophic factors, and extracellular matrix proteins. Overall, contributions in understanding neurogenesis, tissue development, differentiation, connectivity, plasticity, and cell death are widely described. A complete access to the genome of several vertebrates, as well as the recent transcriptome at the single cell level at different stages of development, also anticipates future advances in providing cues to target blinding diseases or retinal dysfunctions.
Funder
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro Conselho Nacional de Desenvolvimento Científico e Tecnológico INCT-INNT IRRF research grant
Subject
Inorganic Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Computer Science Applications,Spectroscopy,Molecular Biology,General Medicine,Catalysis
Reference485 articles.
1. Rediscovering the chick embryo as a model to study retinal development;Vergara;Neural Dev.,2012 2. Tsonis, P.A. (2008). Animal Models in Eye Research, Academic Press. 3. Cebulla, C.M., Zelinka, C.P., Scott, M.A., Lubow, M., Bingham, A., Rasiah, S., Mahmoud, A.M., and Fischer, A.J. (2012). A chick model of retinal detachment: Cone rich and novel. PLoS ONE, 7. 4. Exendin-4 inhibits high glucose-induced oxidative stress in retinal pigment epithelial cells by modulating the expression and activation of p(66)Shc;Cutan. Ocul. Toxicol.,2021 5. Methods of dopamine research in retina cells;Ventura;Methods Mol. Biol.,2013
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