The Impact of 5-Aminolevulinic Acid Supplementation on Redox Balance and Aerobic Capacity
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Published:2024-01-12
Issue:2
Volume:25
Page:988
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ISSN:1422-0067
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Container-title:International Journal of Molecular Sciences
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language:en
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Short-container-title:IJMS
Author:
Saga Norio1ORCID, Hu Ailing2, Yamaguchi Takuji2, Naraoka Yuna3ORCID, Kobayashi Hiroyuki4ORCID
Affiliation:
1. Institute of Sports Science & Medicine, Teikyo University, Tokyo 173-8605, Japan 2. Department of Personalised Kampo Medicine, Juntendo University Graduate School of Medicine, Tokyo 113-8421, Japan 3. Intractable Disease Research Center, Juntendo University Graduate School of Medicine, Tokyo 113-8421, Japan 4. Department of Hospital Administration, Juntendo University Graduate School of Medicine, Tokyo 113-8421, Japan
Abstract
We examined the impact of 5-aminolevulinic acid (5-ALA) and sodium-ferrous-citrate supplementation on aerobic capacity and redox balance through a placebo-controlled, double-blind trial. Fourteen healthy volunteers were randomly assigned to Pla + ALA (4-week placebo followed by 4-week 5-ALA supplementation) or ALA + Pla (4-week 5-ALA supplement followed by a 4-week placebo) group and administered 5-ALA (25 mg/day) or placebo once daily. The participants underwent submaximal incremental cycling tests at weeks 0, 2, 4, 6, and 8. In the cycling test at week 0, individual load-intensity stages required for blood lactate levels >2 mmol/L (lactate threshold, LT) and 4 mmol/L (onset of blood lactate accumulation, OBLA) were determined. The heart rate (HR), blood lactate (La), and oxidative stress markers (diacron reactive oxygen metabolite, d-ROMs; biological antioxidant potential, BAP) were measured at resting, LT, and OBLA states in each cycling test. Marker values were not significantly different between the groups. HR, La, and d-ROMs at resting, LT, and OBLA states were not significantly different among the conditions. BAP and BAP/d-ROMs ratios were significantly different in the OBLA state at week 4 of the 5-ALA group compared with that of the placebo group (p < 0.05). In conclusion, 5-ALA supplementation might improve redox balance during high-intensity aerobic exercise.
Funder
SBI ALApromo Co., Ltd., Tokyo, Japan
Subject
Inorganic Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Computer Science Applications,Spectroscopy,Molecular Biology,General Medicine,Catalysis
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