From Ocean to Medicine: Harnessing Seaweed’s Potential for Drug Development

Author:

Cotas João1ORCID,Lomartire Silvia1,Gonçalves Ana M. M.12ORCID,Pereira Leonel1ORCID

Affiliation:

1. Marine Resources, Conservation and Technology, Marine Algae Lab, CFE—Centre for Functional Ecology: Science for People & Planet, Department of Life Sciences, University of Coimbra, 3000-456 Coimbra, Portugal

2. Department of Biology and CESAM, University of Aveiro, 3810-193 Aveiro, Portugal

Abstract

Seaweed, a miscellaneous group of marine algae, has long been recognized for its rich nutritional composition and bioactive compounds, being considered nutraceutical ingredient. This revision delves into the promising role of seaweed-derived nutrients as a beneficial resource for drug discovery and innovative product development. Seaweeds are abundant sources of essential vitamins, minerals, polysaccharides, polyphenols, and unique secondary metabolites, which reveal a wide range of biological activities. These bioactive compounds possess potential therapeutic properties, making them intriguing candidates for drug leads in various medical applications and pharmaceutical drug development. It explores their pharmacological properties, including antioxidant, anti-inflammatory, antimicrobial, and anticancer activities, shedding light on their potential as therapeutic agents. Moreover, the manuscript provides insights into the development of formulation strategies and delivery systems to enhance the bioavailability and stability of seaweed-derived compounds. The manuscript also discusses the challenges and opportunities associated with the integration of seaweed-based nutrients into the pharmaceutical and nutraceutical industries. Regulatory considerations, sustainability, and scalability of sustainable seaweed sourcing and cultivation methods are addressed, emphasizing the need for a holistic approach in harnessing seaweed’s potential. This revision underscores the immense potential of seaweed-derived compounds as a valuable reservoir for drug leads and product development. By bridging the gap between marine biology, pharmacology, and product formulation, this research contributes to the critical advancement of sustainable and innovative solutions in the pharmaceutical and nutraceutical sectors.

Funder

AlgaMar4antivirus—Marine MacroalgaE in the prevention and treatment of ANTIviral diseases

Blue Fund

Foundation for Science and Technology

University of Coimbra

Publisher

MDPI AG

Subject

Inorganic Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Computer Science Applications,Spectroscopy,Molecular Biology,General Medicine,Catalysis

Reference121 articles.

1. García-Poza, S., Leandro, A., Cotas, J., Pacheco, D., Marques, J.C., Pereira, L., and Gonçalves, A.M.M. (2023). Algal Metabolites, Apple Academic Press.

2. Seaweeds’ Nutraceutical and Biomedical Potential in Cancer Therapy: A Concise Review;Cotas;J. Cancer Metastasis Treat.,2021

3. Lomartire, S., and Gonçalves, A.M.M. (2022). An Overview of Potential Seaweed-Derived Bioactive Compounds for Pharmaceutical Applications. Mar. Drugs, 20.

4. Natural Products in Drug Discovery: Advances and Opportunities;Atanasov;Nat. Rev. Drug Discov.,2021

5. Malve, H. (2016). Exploring the Ocean for New Drug Developments: Marine Pharmacology. J. Pharm. Bioallied. Sci., 8.

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