Electrospun Polymer Nanofibers with Antimicrobial Activity

Abstract

Nowadays, nanofibers with antimicrobial activity are of great importance due to the widespread antibiotic resistance of many pathogens. Electrospinning is a versatile method of producing ultrathin fibers with desired properties, and this technique can be optimized by controlling parameters such as solution/melt viscosity, feeding rate, and electric field. High viscosity and slow feeding rate cause blockage of the spinneret, while low viscosity and high feeding rate result in fiber discontinuities or droplet formation. The electric field must be properly set because high field strength shortens the solidification time of the fluid streams, while low field strength is unable to form the Taylor cone. Environmental conditions, temperature, and humidity also affect electrospinning. In recent years, significant advances have been made in the development of electrospinning methods and the engineering of electrospun nanofibers for various applications. This review discusses the current research on the use of electrospinning to fabricate composite polymer fibers with antimicrobial properties by incorporating well-defined antimicrobial nanoparticles (silver, titanium dioxide, zinc dioxide, copper oxide, etc.), encapsulating classical therapeutic agents (antibiotics), plant-based bioactive agents (crude extracts, essential oils), and pure compounds (antimicrobial peptides, photosensitizers) in polymer nanofibers with controlled release and anti-degradation protection. The analyzed works prove that the electrospinning process is an effective strategy for the formation of antimicrobial fibers for the biomedicine, pharmacy, and food industry.