Affiliation:
1. Laboratory of Ophthalmology, Institute of Neuroscience, Lithuanian University of Health Sciences, LT-50161 Kaunas, Lithuania
2. Medical Faculty, Lithuanian University of Health Sciences, LT-50161 Kaunas, Lithuania
3. Department of Ophthalmology, Lithuanian University of Health Sciences, LT-50161 Kaunas, Lithuania
Abstract
The aim of the study was to evaluate the associations of STAT4 (rs10181656, rs7574865, rs7601754, rs10168266) gene polymorphisms and STAT4 serum level in patients with optic neuritis. Eighty-one subjects with optic neuritis (ON) and 158 healthy subjects participated in the study. Genotyping was performed using real-time polymerase chain reaction to obtain data. STAT4 serum level was determined using the ELISA method. Statistical analysis revealed that STAT4 rs7574865 allele G was statistically significantly more frequent in patients with ON and multiple sclerosis (MS) than in the control group (84.38% vs. 65.93%, p = 0.003). STAT4 rs10168266 allele C was statistically significantly more frequent in the ON group with MS than in the control group (89.06% vs. 71.75%, p = 0.003). The haplotypes G-G-A-C and C-T-A-T of STAT4 (rs10181656, rs7574865, rs7601754, rs10168266) were associated with an 11.5- and 19.5-fold increased odds of ON occurrence (p = 0.003; p = 0.008, respectively). In optic neuritis without MS occurrence, STAT4 (rs10181656, rs7574865, rs7601754, rs10168266) haplotypes G-G-A-C and C-T-A-T were found to be associated with 32.6- and 9-fold increased odds of ON without MS (p = 0.002, p = 0.016, respectively). The current findings may indicate a risk role of STAT4 (rs10181656, rs7574865, rs7601754, rs10168266) G-G-A-C and C-T-A-T haplotypes in the occurrence of optic neuritis.
Reference45 articles.
1. Regos nervo sužalojimas: Literatūros apžvalga;Liet. Chirurgija,2011
2. Lalswani, A.K. (2020). Current Diagnosis & Treatment Otolaryngology—Head and Neck Surgery, McGraw-Hill Education. [4th ed.].
3. Optic neuritis;J. Med. Sci.,2020
4. Optic Neuritis;Bennett;CONTINUUM Lifelong Learning in Neurology,2019
5. Rosa, N., De Bernardo, M., Di Stasi, M., Cione, F., and Capaldo, I. (2022). A-Scan Ultrasonographic Evaluation of Patients with Idiopathic Intracranial Hypertension: Comparison of Optic Nerves. J. Clin. Med., 11.