Affiliation:
1. Department of Biomedical and Neuromotor Sciences, University of Bologna, 40126 Bologna, Italy
2. IRCCS Institute of Neurological Sciences of Bologna, Full Member of the European Reference Network EpiCARE, 40139 Bologna, Italy
Abstract
The most critical burden for People with Epilepsy (PwE) is represented by seizures, the unpredictability of which severely impacts quality of life. The design of real-time warning systems that can detect or even predict ictal events would enhance seizure management, leading to high benefits for PwE and their caregivers. In the past, various research works highlighted that seizure onset is anticipated by significant changes in autonomic cardiac control, which can be assessed through heart rate variability (HRV). This manuscript conducted a scoping review of the literature analyzing HRV-based methods for detecting or predicting ictal events. An initial search on the PubMed database returned 402 papers, 72 of which met the inclusion criteria and were included in the review. These results suggest that seizure detection is more accurate in neonatal and pediatric patients due to more significant autonomic modifications during the ictal transitions. In addition, conventional metrics are often incapable of capturing cardiac autonomic variations and should be replaced with more advanced methodologies, considering non-linear HRV features and machine learning tools for processing them. Finally, studies investigating wearable systems for heart monitoring denoted how HRV constitutes an efficient biomarker for seizure detection in patients presenting significant alterations in autonomic cardiac control during ictal events.
Reference119 articles.
1. What is known about the mechanisms underlying SUDEP?;So;Epilepsia,2008
2. Factors influencing on quality of life in people with epilepsy;Guekht;Seizure,2007
3. Seizure forecasting and cyclic control of seizures;Stirling;Epilepsia,2021
4. Autonomic epilepsy—The influence of epileptic discharges on heart rate and rhythm;Schernthaner;Wien. Klin. Wochenschr.,1999
5. Autonomic alterations and cardiac changes in epilepsy;Sevcencu;Epilepsia,2010
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