Revitalizing the Gut Microbiome in Chronic Kidney Disease: A Comprehensive Exploration of the Therapeutic Potential of Physical Activity-Reference-Cited by-同舟云学术

Revitalizing the Gut Microbiome in Chronic Kidney Disease: A Comprehensive Exploration of the Therapeutic Potential of Physical Activity

Published:2024-05-26 Issue:6 Volume:16 Page:242
ISSN:2072-6651
Container-title:Toxins
language:en
Short-container-title:Toxins

Author:

Vandecruys Marieke¹,De Smet Stefan²^ORCID,De Beir Jasmine³,Renier Marie⁴^ORCID,Leunis Sofie⁵^ORCID,Van Criekinge Hanne⁵^ORCID,Glorieux Griet⁶^ORCID,Raes Jeroen⁷⁸,Vanden Wyngaert Karsten⁶^ORCID,Nagler Evi⁶,Calders Patrick³^ORCID,Monbaliu Diethard⁵⁹,Cornelissen Véronique⁴^ORCID,Evenepoel Pieter¹¹⁰,Van Craenenbroeck Amaryllis H.¹¹⁰^ORCID

Affiliation:

1. Nephrology and Renal Transplantation Research Group, Department of Microbiology, Immunology and Transplantation, KU Leuven, 3000 Leuven, Belgium

2. Exercise Physiology Research Group, Department of Movement Sciences, KU Leuven, 3000 Leuven, Belgium

3. Department of Rehabilitation Sciences, Ghent University, 9000 Ghent, Belgium

4. Group Rehabilitation for Internal Disorders, Department of Rehabilitation Sciences, KU Leuven, 3000 Leuven, Belgium

5. Department of Microbiology, Immunology and Transplantation, Abdominal Transplantation, KU Leuven, 3000 Leuven, Belgium

6. Department of Internal Medicine and Pediatrics, Nephrology Section, Ghent University Hospital, 9000 Ghent, Belgium

7. Department of Microbiology and Immunology, Rega Institute for Medical Research, 3000 Leuven, Belgium

8. VIB-KU Leuven Center for Microbiology, 3000 Leuven, Belgium

9. Transplantoux Foundation, 3000 Leuven, Belgium

10. Department of Nephrology, University Hospitals Leuven, 3000 Leuven, Belgium

Abstract

Both physical inactivity and disruptions in the gut microbiome appear to be prevalent in patients with chronic kidney disease (CKD). Engaging in physical activity could present a novel nonpharmacological strategy for enhancing the gut microbiome and mitigating the adverse effects associated with microbial dysbiosis in individuals with CKD. This narrative review explores the underlying mechanisms through which physical activity may favorably modulate microbial health, either through direct impact on the gut or through interorgan crosstalk. Also, the development of microbial dysbiosis and its interplay with physical inactivity in patients with CKD are discussed. Mechanisms and interventions through which physical activity may restore gut homeostasis in individuals with CKD are explored.

Funder

Research Foundation-Flanders

Publisher

MDPI AG

Link

https://www.mdpi.com/2072-6651/16/6/242/pdf

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