The Evolution of Circulating Biomarkers for Use in Acetaminophen/Paracetamol-Induced Liver Injury in Humans: A Scoping Review-Reference-Cited by-同舟云学术

The Evolution of Circulating Biomarkers for Use in Acetaminophen/Paracetamol-Induced Liver Injury in Humans: A Scoping Review

Published:2023-10-27 Issue:4 Volume:3 Page:569-596
ISSN:2673-4389
Container-title:Livers
language:en
Short-container-title:Livers

Author:

McGill Mitchell R.¹²³^ORCID,Curry Steven C.⁴⁵

Affiliation:

1. Department of Environmental Health Sciences, Fay W. Boozman College of Public Health, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA

2. Department of Pharmacology and Toxicology, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA

3. Department of Pathology, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA

4. Division of Clinical Data Analytics and Decision Support, University of Arizona College of Medicine—Phoenix, Phoenix, AZ 85006, USA

5. Department of Medical Toxicology, Banner—University Medical Center Phoenix, Phoenix, AZ 85006, USA

Abstract

Acetaminophen (APAP) is a widely used drug, but overdose can cause severe acute liver injury. The first reports of APAP hepatotoxicity in humans were published in 1966, shortly after the development of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) as the first biomarkers of liver injury as opposed to liver function. Thus, the field of liver injury biomarkers has evolved alongside the growth in APAP hepatotoxicity incidence. Numerous biomarkers have been proposed for use in the management of APAP overdose patients in the intervening years. Here, we comprehensively review the development of these markers from the 1960s to the present day and briefly discuss possible future directions.

Funder

National Institutes of Health

Haleon

Publisher

MDPI AG

Subject

General Medicine

Link

https://www.mdpi.com/2673-4389/3/4/39/pdf

Reference214 articles.

1. Clinical toxicology in Edinburgh, two centuries of progress;Proudfoot;Clin. Toxicol.,2013

2. Acute liver necrosis following overdose of paracetamol;Davidson;Br. Med. J.,1966

3. Chronic Toxicity Studies on Phenacetin, N-Acetyl-p-Aminophenol (NAPA) and Acetylsalicylic Acid on Cats;Eder;Acta Pharmacol. Toxicol.,1964

4. Liver Necrosis from Paracetamol;Boyd;Br. J. Pharmacol. Chemother.,1966

5. Aspirin and Gastric Bleeding;Bone;Br. Med. J.,1967