Affiliation:
1. Vernadsky Institute of Geochemistry and Analytical Chemistry, Russian Academy of Sciences, 19 Kosygin St., Moscow 119991, Russia
Abstract
Metals are dispersed in natural environments, particularly in the aquatic environment, and accumulate, causing adverse effects on aquatic life. Moreover, chronic polymetallic water pollution is a common problem, and the biological effects of exposure to complex mixtures of metals are the most difficult to interpret. In this review, metal toxicity is examined with a focus on its impact on energy metabolism. Mechanisms regulating adenosine triphosphate (ATP) production and reactive oxygen species (ROS) emission are considered in their dual roles in the development of cytotoxicity and cytoprotection, and mitochondria may become target organelles of metal toxicity when the transmembrane potential is reduced below its phosphorylation level. One of the main consequences of metal toxicity is additional energy costs, and the metabolic load can lead to the disruption of oxidative metabolism and enhanced anaerobiosis.
Funder
Russian Science Foundation
Reference77 articles.
1. Tchounwou, P.B., Yedjou, C.G., Patlolla, A.K., and Sutton, D.J. (2012). Molecular, Clinical and Environmental Toxicology, Springer. V. 3: Environmental Toxicology.
2. Water pollution effect on population health in an industrial northern region;Moiseenko;Water Res.,2010
3. Emerging pollutants in the environment: Present and future challenges in biomonitoring, ecological risks and bioremediation;Gavrilescu;N. Biotechnol.,2015
4. Health risk assessment of heavy metals in freshwater fish in the central and eastern North China;Zhong;Ecotoxicol. Environ. Saf.,2018
5. Surenbaatar, U., Lee, S., Kwon, J.-Y., Lim, H., Kim, J.-J., Kim, Y.-H., and Hong, Y.-S. (2023). Bioaccumulation of Lead, Cadmium, and Arsenic in a Mining Area and Its Associated Health Effects. Toxics, 11.
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