Affiliation:
1. Department of Immunology, Genetics and Pathology, Uppsala University, SE-751 85 Uppsala, Sweden
Abstract
The cytoskeleton plays a pivotal role in maintaining the epithelial phenotype and is vital to several hallmark processes of cancer. Over the past decades, researchers have identified the epithelial protein lost in neoplasm (EPLIN, also known as LIMA1) as a key regulator of cytoskeletal dynamics, cytoskeletal organization, motility, as well as cell growth and metabolism. Dysregulation of EPLIN is implicated in various aspects of cancer progression, such as tumor growth, invasion, metastasis, and therapeutic resistance. Its altered expression levels or activity can disrupt cytoskeletal dynamics, leading to aberrant cell motility and invasiveness characteristic of malignant cells. Moreover, the involvement of EPLIN in cell growth and metabolism underscores its significance in orchestrating key processes essential for cancer cell survival and proliferation. This review provides a comprehensive exploration of the intricate roles of EPLIN across diverse cellular processes in both normal physiology and cancer pathogenesis. Additionally, this review discusses the possibility of EPLIN as a potential target for anticancer therapy in future studies.
Reference91 articles.
1. Hallmarks of Cancer: New Dimensions;Hanahan;Cancer Discov.,2022
2. Gene Expression Profiles in Cancers and Their Therapeutic Implications;Creighton;Cancer J.,2023
3. Kim, Y.J., Cho, M.J., Yu, W.D., Kim, M.J., Kim, S.Y., and Lee, J.H. (2022). Links of Cytoskeletal Integrity with Disease and Aging. Cells, 11.
4. Towards understanding epithelial-mesenchymal transition: A proteomics perspective;Mathias;Biochim. Biophys. Acta,2009
5. Regulation of cancer cell motility through actin reorganization;Yamazaki;Cancer Sci.,2005