Anti-Inflammatory and Anticancer Effects of Anticoagulant Therapy in Patients with Malignancy-Reference-Cited by-同舟云学术

Anti-Inflammatory and Anticancer Effects of Anticoagulant Therapy in Patients with Malignancy

Published:2023-09-10 Issue:9 Volume:13 Page:1888
ISSN:2075-1729
Container-title:Life
language:en
Short-container-title:Life

Author:

Russo Vincenzo¹²^ORCID,Falco Luigi¹,Tessitore Viviana¹,Mauriello Alfredo¹^ORCID,Catapano Dario¹,Napolitano Nicola¹,Tariq Moiz¹,Caturano Alfredo³^ORCID,Ciccarelli Giovanni¹²^ORCID,D’Andrea Antonello³⁴^ORCID,Giordano Antonio²

Affiliation:

1. Cardiology Unit, Department of Medical Translational Science, University of Campania “Luigi Vanvitelli”—Monaldi Hospital, 80126 Naples, NA, Italy

2. Sbarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology, College of Science and Technology, Temple University, Philadelphia, PA 19122, USA

3. Department of Advanced Medical and Surgical Sciences, University of Campania Luigi Vanvitelli, Piazza Luigi Miraglia 2, 80138 Naples, NA, Italy

4. Cardiology Unit, Umberto I Hospital, 84014 Nocera Inferiore, SA, Italy

Abstract

Optimizing the anticoagulation therapy is of pivotal importance in patients with a malignant tumor, as venous thromboembolism (VTE) has become the second-leading cause of death in this population. Cancer can highly increase the risk of thrombosis and bleeding. Consequently, the management of cancer-associated VTE is complex. In recent years, translational research has intensified, and several studies have highlighted the role of inflammatory cytokines in cancer growth and progression. Simultaneously, the pleiotropic effects of anticoagulants currently recommended for VTE have emerged. In this review, we describe the anti-inflammatory and anticancer effects of both direct oral anticoagulants (DOACs) and low-molecular-weight heparins (LWMHs).

Publisher

MDPI AG

Subject

Paleontology,Space and Planetary Science,General Biochemistry, Genetics and Molecular Biology,Ecology, Evolution, Behavior and Systematics

Link

https://www.mdpi.com/2075-1729/13/9/1888/pdf

Reference126 articles.

1. Venous Thromboembolism in Cancer Patients: A Population-Based Cohort Study;Mulder;Blood,2021

2. Thromboembolism Is a Leading Cause of Death in Cancer Patients Receiving Outpatient Chemotherapy;Khorana;J. Thromb. Haemost.,2007

3. Low-Molecular-Weight Heparin versus a Coumarin for the Prevention of Recurrent Venous Thromboembolism in Patients with Cancer;Lee;N. Engl. J. Med.,2003

4. Editor’s Choice—A Systematic Review and Meta-Analysis of the Efficacy and Safety of Anticoagulation in the Treatment of Venous Thromboembolism in Patients with Cancer;Kirkilesis;Eur. J. Vasc. Endovasc. Surg.,2019

5. Current Practice Patterns and Patient Persistence with Anticoagulant Treatments for Cancer-associated Thrombosis;Khorana;Res. Pract. Thromb. Haemost.,2017

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