Comprehensive Analysis of Novel Synergistic Antioxidant Formulations: Insights into Pharmacotechnical, Physical, Chemical, and Antioxidant Properties-Reference-Cited by-同舟云学术

Comprehensive Analysis of Novel Synergistic Antioxidant Formulations: Insights into Pharmacotechnical, Physical, Chemical, and Antioxidant Properties

Published:2024-05-27 Issue:6 Volume:17 Page:690
ISSN:1424-8247
Container-title:Pharmaceuticals
language:en
Short-container-title:Pharmaceuticals

Author:

Neacșu Sorinel Marius¹,Mititelu Magdalena²^ORCID,Ozon Emma Adriana¹,Musuc Adina Magdalena³^ORCID,Iuga Izabela Dana Maria²,Manolescu Bogdan Nicolae⁴,Petrescu Simona³,Pandele Cusu Jeanina³,Rusu Adriana³,Surdu Vasile-Adrian⁵^ORCID,Oprea Eliza⁶^ORCID,Lupuliasa Dumitru¹,Popescu Ioana Andreea¹

Affiliation:

1. Department of Pharmaceutical Technology and Biopharmacy, Faculty of Pharmacy, “Carol Davila” University of Medicine and Pharmacy, 6 Traian Vuia Street, 020945 Bucharest, Romania

2. Department of Clinical Laboratory and Food Safety, Faculty of Pharmacy, “Carol Davila” University of Medicine and Pharmacy, 6 Traian Vuia Street, 020945 Bucharest, Romania

3. Institute of Physical Chemistry—Ilie Murgulescu, Romanian Academy, 202 Spl. Independentei, 060021 Bucharest, Romania

4. “C. Nenitescu” Department of Organic Chemistry, Faculty of Applied Chemistry and Science of Materials, National University for Science and Technology Politehnica Bucharest, 1–7 Gh. Polizu Street, 011061 Bucharest, Romania

5. Department of Science and Engineering of Oxide Materials and Nanomaterials, Faculty of Chemical Engineering and Biotechnologies, National University for Science and Technology Politehnica Bucharest, 1–7 Gh. Polizu Street, 011061 Bucharest, Romania

6. Department of Microbiology, Faculty of Biology, University of Bucharest, 1–3 Portocalilor Way, 060101 Bucharest, Romania

Abstract

(1) Background: Oxidative stress plays a pivotal role in the pathogenesis of various diseases, including neurodegenerative disorders, cardiovascular diseases, cancer, and diabetes, highlighting the pressing need for effective antioxidant interventions. (2) Methods: In this study, we aimed to develop and characterise two novel antioxidant formulations, F3 and F4, as therapeutic interventions for oxidative stress-related conditions. (3) Results: The physicochemical characterisation, preformulation analysis, formulation, preparation of filling powders for capsules, capsule content evaluation, and antioxidant activity assessment of the two novel antioxidant formulations were assessed. These formulations comprise a combination of well-established antioxidants like quercetin, biotin, coenzyme Q10, and resveratrol. Through comprehensive testing, the formulations’ antioxidant efficacy, stability, and potential synergistic interactions were evaluated. (4) Conclusions: The findings underscore the promising potential of these formulations as therapeutic interventions for oxidative stress-related disorders and highlight the significance of antioxidant interventions in mitigating their progression.

Publisher

MDPI AG

Link

https://www.mdpi.com/1424-8247/17/6/690/pdf

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