Stroke and Risk Factors in Antiphospholipid Syndrome

Author:

Fan Yangyi1,Xu Yicheng2,Zhang Sifan3,Song Xiaodong14,Liu Zunjing1,Tu Wenjun5ORCID,Li Chun6

Affiliation:

1. Department of Neurology, Peking University People’s Hospital, Beijing 100044, China

2. Department of Neurology, Aerospace Center Hospital, Beijing 100049, China

3. Peking University People’s Hospital, Beijing 100191, China

4. Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400042, China

5. Department of Neurosurgery, Tiantan Hospital, Beijing 100050, China

6. Department of Rheumatology and Immunology, Peking University People’s Hospital, Beijing 100044, China

Abstract

Stroke is considered one of the most common and life-threatening manifestations of antiphospholipid syndrome (APS), which leads to high mortality and permanent disability. This study investigated the prevalence and the potential risk factors of stroke in APS. We enrolled 361 APS patients retrospectively from 2009 to 2022 at Peking University People’s Hospital. Stroke was found in 25.8% (93/361) of the participants. The multivariate logistic regression showed that hypertension, diabetes, livedo reticularis, and other central nervous system involvements were significant related factors for stroke. The use of hydroxychloroquine appeared to relate to a lower incidence of stroke. During a median follow-up of 3.0 years, 11.8% (11/93) of the individuals with a previous stroke developed stroke recurrence, and thrombocytopenia seemed to be a predictor of stroke recurrence.

Funder

China International Medical Foundation

Beijing Natural Science Foundation

Research and Development Fund of Peking University People’s Hospital

Publisher

MDPI AG

Subject

Medicine (miscellaneous)

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