Author:
Cong Ye,Han Xiahe,Wang Youping,Chen Zongzheng,Lu Yao,Liu Tingjiao,Wu Zhengzhi,Jin Yu,Luo Yong,Zhang Xiuli
Abstract
Organ-on-a-chip academic research is in its blossom. Drug toxicity evaluation is a promising area in which organ-on-a-chip technology can apply. A unique advantage of organ-on-a-chip is the ability to integrate drug metabolism and drug toxic processes in a single device, which facilitates evaluation of toxicity of drug metabolites. Human organ-on-a-chip has been fabricated and used to assess drug toxicity with data correlation with the clinical trial. In this review, we introduced the microfluidic chip models of liver, kidney, heart, nerve, and other organs and multiple organs, highlighting the application of these models in drug toxicity detection. Some biomarkers of toxic injury that have been used in organ chip platforms or have potential for use on organ chip platforms are summarized. Finally, we discussed the goals and future directions for drug toxicity evaluation based on organ-on-a-chip technology.
Funder
National Natural Science Foundation of China
National Key Research and Development Program of China
Shenzhen Fundamental Research and Discipline Layout project
China Postdoctoral Science Foundation
Sanming Project of Medicine in Shenzhen
Subject
Electrical and Electronic Engineering,Mechanical Engineering,Control and Systems Engineering
Cited by
99 articles.
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