Liver-Targeted Nanoparticles Loaded with Cannabidiol Based on Redox Response for Effective Alleviation of Acute Liver Injury-Reference-Cited by-同舟云学术

Liver-Targeted Nanoparticles Loaded with Cannabidiol Based on Redox Response for Effective Alleviation of Acute Liver Injury

Published:2024-08-04 Issue:15 Volume:13 Page:2464
ISSN:2304-8158
Container-title:Foods
language:en
Short-container-title:Foods

Author:

Zhang Xuan¹²³,Yi Xiangzhou¹²³,Gao Xia¹²³,Li Yongcheng¹²³,Shen Xuanri¹²³⁴^ORCID

Affiliation:

1. School of Food Science and Engineering, Hainan University, Haikou 570228, China

2. Key Laboratory of Food Nutrition and Functional Food of Hainan Province, Haikou 570228, China

3. Hainan Engineering Research Center of Aquatic Resources Efficient Utilization in South China Sea, Hainan University, Haikou 570228, China

4. College of Food Science and Engineering, Hainan Tropical Ocean University, Sanya 572022, China

Abstract

The purpose of this work was to construct liver-targeted nanoparticles based on the redox response to effectively deliver cannabidiol (CBD) for the prevention of acute liver injury (ALI). CBD-loaded nanoparticles (CBD NPs) with a particle size of 126.5 ± 1.56 nm were prepared using the polymer DA-PP-LA obtained by grafting pullulan polysaccharide with deoxycholic acid (DA) and α-lipoic acid (α-LA). CBD NPs showed typical redox-response release behavior. Interestingly, CBD NPs exhibited admirable liver targeting ability, significantly accumulated in the liver, and effectively promoted the internalization of CBD in liver cells, thus effectively reducing the H2O2-induced oxidative damage of HepG2 cells and avoiding apoptosis. More importantly, CBD NPs effectively prevented CCl4-induced ALI by protecting liver function, ameliorating oxidative stress levels, inhibiting the production of inflammatory factors, and protecting the liver from histological damage. This study provides a promising strategy for achieving targeted delivery of CBD NPs in the liver, thereby effectively preventing ALI.

Funder

Scientific Research Foundation of Hainan Tropical Ocean University

Publisher

MDPI AG

Link

https://www.mdpi.com/2304-8158/13/15/2464/pdf

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