Abstract
Food protein or food-derived peptides may regulate blood glucose levels; however, studies have shown inconsistent results. The aim of the present study was to characterize subgroups of individuals with increased risk of type 2 diabetes (T2D) and to investigate the cardiometabolic effects of fish protein in the same subgroups. We first divided participants into high insuliniAUC and low insuliniAUC subjects based on their insulin incremental area under the curve (iAUC) levels after a 2 h oral glucose tolerance test (OGTT), and secondly based on whether they had received 5.2 g salmon fish protein or placebo for 8 weeks, in a previously conducted randomized controlled trial (RCT). We then profiled these groups by analyzing plasma metabolomics and peripheral blood mononuclear cell (PBMC) gene expression. Compared to the low insuliniAUC group, the high insuliniAUC group had higher plasma concentrations of monounsaturated fatty acids (MUFAs) and glycated proteins (GlycA) and lower concentrations of glycine and acetate. After intervention with fish protein compared to placebo, however, only acetate was significantly increased in the low insuliniAUC group. In conclusion, we identified metabolic biomarkers known to be associated with T2D; also, intervention with fish protein did not affect cardiometabolic risk markers in subgroups with increased risk of T2D.
Funder
University of Oslo
The Throne Holst Foundation for Nutrition Research
FHF—Norwegian Seafood Research Fund
Generalitat Valenciana and the European Social Fund
Subject
Food Science,Nutrition and Dietetics
Reference70 articles.
1. Global aetiology and epidemiology of type 2 diabetes mellitus and its complications;Zheng;Nat. Rev. Endocrinol.,2018
2. Type 2 diabetes mellitus;DeFronzo;Nat. Rev. Dis. Primers,2015
3. Diagnosis and classification of diabetes mellitus;Diabetes Care,2013
4. Alok, K., Gupta, A.M., Brashear, M., and William, D.J. (2018). Nutritional and Therapeutic Interventions for Diabetes and Metabolic Syndrome, Academic Press. [2nd ed.].
5. Minireview: The adipocyte--at the crossroads of energy homeostasis, inflammation, and atherosclerosis;Rajala;Endocrinology,2003
Cited by
1 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献