Research into New Molecular Mechanisms in Thrombotic Diseases Paves the Way for Innovative Therapeutic Approaches
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Published:2024-02-21
Issue:5
Volume:25
Page:2523
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ISSN:1422-0067
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Container-title:International Journal of Molecular Sciences
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language:en
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Short-container-title:IJMS
Author:
Sacchetti Sara1ORCID, Puricelli Chiara1ORCID, Mennuni Marco2, Zanotti Valentina1ORCID, Giacomini Luca1ORCID, Giordano Mara1ORCID, Dianzani Umberto1, Patti Giuseppe2ORCID, Rolla Roberta1ORCID
Affiliation:
1. Clinical Chemistry Laboratory, “Maggiore della Carità” University Hospital, Department of Health Sciences, University of Eastern Piedmont, 28100 Novara, Italy 2. Division of Cardiology, “Maggiore della Carità” University Hospital, Department of Translational Medicine, University of Eastern Piedmont, 28100 Novara, Italy
Abstract
Thrombosis is a multifaceted process involving various molecular components, including the coagulation cascade, platelet activation, platelet–endothelial interaction, anticoagulant signaling pathways, inflammatory mediators, genetic factors and the involvement of various cells such as endothelial cells, platelets and leukocytes. A comprehensive understanding of the molecular signaling pathways and cell interactions that play a role in thrombosis is essential for the development of precise therapeutic strategies for the treatment and prevention of thrombotic diseases. Ongoing research in this field is constantly uncovering new molecular players and pathways that offer opportunities for more precise interventions in the clinical setting. These molecular insights into thrombosis form the basis for the development of targeted therapeutic approaches for the treatment and prevention of thrombotic disease. The aim of this review is to provide an overview of the pathogenesis of thrombosis and to explore new therapeutic options.
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