Acquired and Inherited Zinc Deficiency-Related Diseases in Children: A Case Series and a Narrative Review-Reference-Cited by-同舟云学术

Acquired and Inherited Zinc Deficiency-Related Diseases in Children: A Case Series and a Narrative Review

Published:2024-07-25 Issue:3 Volume:16 Page:602-617
ISSN:2036-7503
Container-title:Pediatric Reports
language:en
Short-container-title:Pediatric Reports

Author:

Bellini Tommaso¹^ORCID,Bustaffa Marta¹,Tubino Barbara¹,Giordano Benedetta²,Formigoni Clelia²,Fueri Elena²,Casabona Federica²,Vanorio Barbara²,Pastorino Andrea²,Herzum Astrid³,Matucci-Cerinic Caterina⁴^ORCID,Arrigo Serena⁵,Viglizzo Gianmaria³,Piccotti Emanuela¹

Affiliation:

1. Pediatric Emergency Room and Emergency Medicine Unit, Emergency Department, IRCCS Istituto Giannina Gaslini, 16147 Genoa, Italy

2. Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal, and Child Health (DINOGMI), University of Genoa, 16132 Genoa, Italy

3. Dermatology Unit, IRCCS Istituto Giannina Gaslini, 16147 Genoa, Italy

4. Reumatology and Autoinflammatory Diseases Unit, IRCCS Istituto Giannina Gaslini, 16147 Genoa, Italy

5. Gastroenterology and Digestive Endoscopy Unit, IRCCS Istituto Giannina Gaslini, 16147 Genoa, Italy

Abstract

Zinc deficiency is a significant global health concern among children, manifesting in various acquired and inherited conditions. This comprehensive overview of acquired and inherited zinc deficiency-related diseases in children aimed to explore the clinical presentations, diagnostic challenges, and management strategies associated with these conditions. This case series elucidates the diverse clinical manifestations of zinc deficiency in pediatric patients, ranging from dermatitis and growth retardation to immune dysregulation and neurological abnormalities, and discusses the underlying genetic mechanisms, clinical phenotypes, and therapeutic interventions. The complexity of zinc deficiency-related diseases in children underscores the need for a multidisciplinary approach involving pediatricians, dermatologists, geneticists, and nutritionists to optimize patient care and outcomes.

Publisher

MDPI AG

Link

https://www.mdpi.com/2036-7503/16/3/51/pdf

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