Association of Methylenetetrahydrofolate Reductase (MTHFR) Polymorphism with Osteosarcoma in a Mexican Population-Reference-Cited by-同舟云学术

Association of Methylenetetrahydrofolate Reductase (MTHFR) Polymorphism with Osteosarcoma in a Mexican Population

Published:2024-09-09 Issue:3 Volume:16 Page:786-793
ISSN:2036-7503
Container-title:Pediatric Reports
language:en
Short-container-title:Pediatric Reports

Author:

Enriquez-Maldonado Irma G.¹,Montes-Galindo Daniel A.²^ORCID,Ortiz-Lopez Rocio³^ORCID,Ojeda-Ibarra Jesus⁴,Martinez-Fierro Margarita L.⁵^ORCID,Rodriguez-Sanchez Iram P.⁶^ORCID,Rojas-Martinez Augusto³,Zavala-Pompa Angel⁴,Sanchez-Ramirez Carmen Alicia⁷^ORCID,Hernandez-Rangel Alejandra E.⁷,Sanchez-Meza Karmina⁷^ORCID,Garza-Veloz Idalia⁵^ORCID,Rodriguez-Hernandez Alejandrina⁷,Delgado-Enciso Ivan¹⁷⁸^ORCID

Affiliation:

1. State Cancerology Institute of Colima, Health Services of the Mexican Social Security Institute for Welfare (IMSS-BIENESTAR), Colima 28085, Mexico

2. Faculty of Chemical Sciences, University of Colima, Coquimatlán 28400, Mexico

3. Tecnologico de Monterrey, Escuela de Medicina y Ciencias de la Salud, Monterrey 64710, Mexico

4. Department of Pathological Anatomy at Monterrey Specialty Hospital No. 25 (IMSS), Monterrey 64460, Mexico

5. Academic Unit of Human Medicine and Health Sciences, Autonomous University of Zacatecas, Zacatecas 98160, Mexico

6. Molecular and Structural Physiology Laboratory, School of Biological Sciences, Autonomous University of Nuevo Leon, San Nicolás de los Garza 66455, Mexico

7. School of Medicine, University of Colima, Colima 28040, Mexico

8. Robert Stempel College of Public Health and Social Work, Florida International University, Miami, FL 33199, USA

Abstract

The methylenetetrahydrofolate reductase (MTHFR) gene 677C➔T polymorphism is capable of altering folate metabolism and can modify certain neoplasia risk. Reports have suggested that folate can have an influence on bone development and so it is of interest to know if the MTHFR 677C➔T polymorphism is associated with the malignant transformation process of this tissue. The polymorphism was determined in 55 patients with osteosarcoma and in 180 healthy individuals. Compared with C/T+C/C genotypes, a 3.7-fold reduction in osteosarcoma probability is possible with the T/T genotype (OR 0.27, CI 95% 0.07–0.82). Undoubtedly, further studies, utilizing large samples and carried out on different populations, are necessary to confirm these results.

Publisher

MDPI AG

Link

https://www.mdpi.com/2036-7503/16/3/66/pdf

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