Unveiling a Dermatological Rarity: The Enigma of Vulvar Intraepithelial Neoplasia Grade III (HSIL) and the Role of p53 in Its Development-Reference-Cited by-同舟云学术

Unveiling a Dermatological Rarity: The Enigma of Vulvar Intraepithelial Neoplasia Grade III (HSIL) and the Role of p53 in Its Development

Published:2024-08-08 Issue:8 Volume:12 Page:1799
ISSN:2227-9059
Container-title:Biomedicines
language:en
Short-container-title:Biomedicines

Author:

Brzeziński Piotr¹,Feszak Igor¹^ORCID,Ortiz Beatriz Di Martino²,Feszak Sylwia³,Kawczak Piotr⁴^ORCID,Bączek Tomasz⁴⁵

Affiliation:

1. Institute of Health Sciences, Pomeranian University in Słupsk, 76-200 Słupsk, Poland

2. Dermatology Department, Clinicas Hospital, Faculty of Medical Sciences, National University of Ausunción, San Lorenzo 111421, Paraguay

3. Department of Genetics and Pathology, International Hereditary Cancer Center, Pomeranian Medical University, ul. Unii Lubelskiej 1, 71-252 Szczecin, Poland

4. Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Medical University of Gdańsk, 80-416 Gdańsk, Poland

5. Department of Nursing and Medical Rescue, Institute of Health Sciences, Pomeranian University in Słupsk, 76-200 Słupsk, Poland

Abstract

Vulvar intraepithelial neoplasia, also known as VIN, is a non-invasive squamous lesion and precursor of squamous cell carcinoma (SCC) of the vulva. There is no screening test for vulvar intraepithelial neoplasia. Diagnosis of VIN is made clinically and confirmed with a biopsy. We describe a 66-year-old woman with a condyloma-like tumour located in the skin on the vestibule of the vagina. A biopsy sample was taken from the nodule. The definitive diagnosis is supported by the histological examination (VIN III) and immunohistochemical examination of p16(+), p53(+), and a few cell nuclei. The case provides information on the importance of multidisciplinary cooperation. Lifelong surveillance is essential since the resection of individual lesions does not guarantee the prevention of invasive cancer.

Publisher

MDPI AG

Link

https://www.mdpi.com/2227-9059/12/8/1799/pdf

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