Abstract
Cannabis is a complex biosynthetic plant, with a long history of medicinal use. While cannabinoids have received the majority of the attention for their psychoactive and pharmacological activities, cannabis produces a diverse array of phytochemicals, such as terpenes. These compounds are known to play a role in the aroma and flavor of cannabis but are potent biologically active molecules that exert effects on infectious as well as chronic diseases. Furthermore, terpenes have the potential to play important roles, such as synergistic and/or entourage compounds that modulate the activity of the cannabinoids. This review highlights the diversity and bioactivities of terpenes in cannabis, especially minor or secondary terpenes that are less concentrated in cannabis on a by-mass basis. We also explore the question of the entourage effect in cannabis, which studies to date have supported or refuted the concept of synergy in cannabis, and where synergy experimentation is headed, to better understand the interplay between phytochemicals within Cannabis sativa L.
Funder
USDA National Institute of Food and Agriculture’s Hatch Appropriations
Subject
General Biochemistry, Genetics and Molecular Biology,Medicine (miscellaneous)
Reference218 articles.
1. Cannabis in Chinese Medicine: Are Some Traditional Indications Referenced in Ancient Literature Related to Cannabinoids?;Brand;Front. Pharmacol.,2017
2. Agrawal, D.C., Kumar, R., and Dhanasekaran, M. (2022). Cannabis/Marijuana for Healthcare, Springer Nature.
3. Cannabis Sativa: A Comprehensive Ethnopharmacological Review of a Medicinal Plant with a Long History;Bonini;J. Ethnopharmacol.,2018
4. Pharmacological Properties, Therapeutic Potential, and Legal Status of Cannabis sativa L.: An Overview;Kumar;Phytother. Res.,2021
5. Recent Advances in Cannabis Sativa Genomics Research;Hurgobin;New Phytol.,2021
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