Affiliation:
1. Department of Cardiac, Thoracic, Vascular Sciences and Public Health, Medical School, University of Padua, 35121 Padova, Italy
Abstract
The history of arrhythmogenic cardiomyopathy (AC) as a genetically determined desmosomal disease started since the original discovery by Lancisi in a four-generation family, published in 1728. Contemporary history at the University of Padua started with Dalla Volta, who haemodynamically investigated patients with “auricularization” of the right ventricle, and with Nava, who confirmed familiarity. The contemporary knowledge advances consisted of (a) AC as a heart muscle disease with peculiar electrical instability of the right ventricle; (b) the finding of pathological substrates, in keeping with a myocardial dystrophy; (c) the inclusion of AC in the cardiomyopathies classification; (d) AC as the main cause of sudden death in athletes; (e) the discovery of the culprit genes coding proteins of the intercalated disc (desmosome); (f) progression in clinical diagnosis with specific ECG abnormalities, angiocardiography, endomyocardial biopsy, 2D echocardiography, electron anatomic mapping and cardiac magnetic resonance; (g) the discovery of left ventricular AC; (h) prevention of SCD with the invention and application of the lifesaving implantable cardioverter defibrillator and external defibrillator scattered in public places and playgrounds as well as the ineligibility for competitive sport activity for AC patients; (i) genetic screening of the proband family to unmask asymptomatic carriers. Nondesmosomal ACs, with a phenotype overlapping desmosomal AC, are also treated, including genetics: Transmembrane protein 43, SCN5A, Desmin, Phospholamban, Lamin A/C, Filamin C, Cadherin 2, Tight junction protein 1.
Funder
Registry of Cardio-Cerebro-Vascular Pathology, Veneto Region, Venice
ARCA Foundation, Padua, Italy
Subject
General Biochemistry, Genetics and Molecular Biology,Medicine (miscellaneous)
Reference110 articles.
1. History of the discovery of Arrhythmogenic Cardiomyopathy;Marrone;Eur. Heart J.,2019
2. Lancisi, G.M. (1728). De Motu Cordis et Aneurysmatibus, G.M. Salvioni. Book II, Ch. VI, Par. XLVII.
3. Lancisi, G.M. (1736). De Motu Cordis et Aneurysmatibus, Caput V.
4. Hippocrates On Diseases, Book I; Sacred Disease; Book V.
5. Laennec, R. (1819). De L’Auscultation Médiate ou Traité du Diagnostic des Maladies des Poumons et du Coeur, Fondé Principalment sur ce Nouveau Moyen d’Exploration, Brosson & Chaudé. Book II, Ch. XV.
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