Hypoxic State of Cells and Immunosenescence: A Focus on the Role of the HIF Signaling Pathway-Reference-Cited by-同舟云学术

Hypoxic State of Cells and Immunosenescence: A Focus on the Role of the HIF Signaling Pathway

Published:2023-08-01 Issue:8 Volume:11 Page:2163
ISSN:2227-9059
Container-title:Biomedicines
language:en
Short-container-title:Biomedicines

Author:

Troise Dario¹^ORCID,Infante Barbara¹,Mercuri Silvia¹,Netti Giuseppe Stefano²^ORCID,Ranieri Elena²^ORCID,Gesualdo Loreto³,Stallone Giovanni¹,Pontrelli Paola³^ORCID

Affiliation:

1. Nephrology, Dialysis and Transplantation Unit, Advanced Research Center on Kidney Aging (A.R.K.A.), Department of Medical and Surgical Science, University of Foggia, 71122 Foggia, Italy

2. Clinical Pathology Unit, Department of Medical and Surgical Sciences, University of Foggia, 71122 Foggia, Italy

3. Nephrology, Dialysis and Transplantation Unit, Department of Precision and Regenerative Medicine and Ionian Area (DiMePRe-J), University of Bari “Aldo Moro”, Policlinico, Piazza Giulio Cesare 11, 70124 Bari, Italy

Abstract

Hypoxia activates hypoxia-related signaling pathways controlled by hypoxia-inducible factors (HIFs). HIFs represent a quick and effective detection system involved in the cellular response to insufficient oxygen concentration. Activation of HIF signaling pathways is involved in improving the oxygen supply, promoting cell survival through anaerobic ATP generation, and adapting energy metabolism to meet cell demands. Hypoxia can also contribute to the development of the aging process, leading to aging-related degenerative diseases; among these, the aging of the immune system under hypoxic conditions can play a role in many different immune-mediated diseases. Thus, in this review we aim to discuss the role of HIF signaling pathways following cellular hypoxia and their effects on the mechanisms driving immune system senescence.

Publisher

MDPI AG

Subject

General Biochemistry, Genetics and Molecular Biology,Medicine (miscellaneous)

Link

https://www.mdpi.com/2227-9059/11/8/2163/pdf

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