Functional Recovery after the Application of Amniotic Tissues and Methylene Blue during Radical Prostatectomy

Functional Recovery after the Application of Amniotic Tissues and Methylene Blue during Radical Prostatectomy—A Pilot Study

Published:2023-08-13 Issue:8 Volume:11 Page:2260
ISSN:2227-9059
Container-title:Biomedicines
language:en
Short-container-title:Biomedicines

Author:

Barski Dimitri¹,Tsaur Igor²^ORCID,Boros Mihaly³,Brune Jan⁴^ORCID,Otto Thomas¹⁵

Affiliation:

1. Department of Urology, Rheinland Klinikum Neuss, 41464 Neuss, Germany

2. Department for Urology and Pediatric Urology, University Medical Center of Johannes Gutenberg, 55131 Mainz, Germany

3. Institute of Surgical Research, University of Szeged, 6720 Szeged, Hungary

4. DIZG—Deutsches Institut für Zell-und Gewebeersatz gGmbH, 12555 Berlin, Germany

5. Medical School, University of Duisburg-Essen, 45147 Essen, Germany

Abstract

Amniotic tissues and methylene blue (MB) provide the ability for neuroregeneration, and MB enables intraoperative neurostaining. We first combined the techniques to explore a neuroprotective effect on early functional outcomes in a retrospective proof-of-concept trial of 14 patients undergoing radical prostatectomy (RP). The patients were followed up at a median of 13 months, and the continence and potency rates were reported. Early recovery of continence was found after three months. No effect on potency was detected. The findings indicate the feasibility of this tissue-engineering strategy, and justify prospective comparative studies.

Publisher

MDPI AG

Subject

General Biochemistry, Genetics and Molecular Biology,Medicine (miscellaneous)

Link

https://www.mdpi.com/2227-9059/11/8/2260/pdf

Reference38 articles.

1. Stratification of postprostatectomy urinary function using expanded prostate cancer index composite;Ellison;Urology,2013

2. Systematic review and meta-analysis of studies reporting urinary continence recovery after robot-assisted radical prostatectomy;Ficarra;Eur. Urol.,2012

3. Postprostatectomy Erectile Dysfunction: A Review;Capogrosso;World J. Men’s Health,2016

4. Laparoscopic and robotic-assisted versus open radical prostatectomy for the treatment of localised prostate cancer;Ilic;Cochrane Database Syst. Rev.,2017

5. Haney, C.M., Kowalewski, K.-F., Westhoff, N., Holze, S., Checcuci, E., Neuberger, M., Haapiainen, H., Egen, L., Antti, K., and Porpiglia, F. Robot-assisted versus Conventional Laparoscopic Radical Prostatectomy: A Systematic Review and Meta-analysis of Randomised Controlled Trials. Eur. Urol. Focus, 2023. in press.