Abstract
Background: Osteopontin, an extracellular matrix protein involved in bone remodeling, tissue repair and inflammation, has previously been associated with increased inflammation and neurodegeneration in multiple sclerosis (MS), promoting a worse disease course. Osteopontin is also likely involved in acute MS relapses. Methods: In 47 patients with relapsing-remitting MS, we explored the correlation between the time elapsed between the last clinical relapse and lumbar puncture, and the cerebrospinal fluid (CSF) levels of osteopontin and a group of inflammatory cytokines and adipokines such as resistin, plasminogen activator inhibitor-1, osteoprotegerin, interleukin (IL)-1β, IL-2, IL-6 and IL-1 receptor antagonist (IL-1ra). We also analyzed the correlations between CSF levels of osteopontin and the other CSF molecules considered. Results: Osteopontin CSF concentrations were higher in patients with a shorter time interval between the last clinical relapse and CSF withdrawal. In addition, CSF levels of osteopontin were positively correlated with the proinflammatory cytokines IL-2 and IL-6 and negatively correlated with the anti-inflammatory molecule IL-1ra. Conclusions: Our results further suggest the role of osteopontin in acute MS relapses showing that, in proximity to relapses, osteopontin expression in CSF may be increased along with other proinflammatory mediators and correlated with decreased concentrations of anti-inflammatory molecules.
Funder
Ministero della Salute (Ministry of Health, Italy): Diego Centonze and Georgia Mandolesi
Ministero della Salute (Ministry of Health, Italy): Fabio Buttari
Ministero della Salute (Ministry of Health, Italy): Progetto Ricerca Corrente to IRCCS Neuromed
Ministero della Salute (Ministry of Health, Italy): Progetto Ricerca Corrente to IRCCS San Raffaele
Georgia Mandolesi
Fondazione Italiana Sclerosi Multipla
Fondazione Italiana Sclerosi Multipla (FISM): Diego Centonze
Fondazione Italiana Sclerosi Multipla (FISM): Mario Stampanoni Bassi
Project ‘Nuovi Biomarker Diagnostici e Terapeutici delle Malattie Neurodegenerative’ - ADOPT co-funded by FOE 2020 - funding from CNR to Diego Centonze
Fondazione Italiana Sclerosi Multipla (FISM): Giuseppe Matarese
Progetti di Rilevante Interesse Nazionale (PRIN): Giuseppe Matarese
Ministero della Salute (Ministry of Health, Italy): Giuseppe Matarese
Subject
General Biochemistry, Genetics and Molecular Biology,Medicine (miscellaneous)
Cited by
3 articles.
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