Cell Technologies in the Stress Urinary Incontinence Correction

Author:

Maiborodin Igor,Yarin Gennadiy,Marchukov Sergey,Pichigina Aleksandra,Lapii Galina,Krasil’nikov Sergey,Senchukova Svetlana,Ryaguzov Maxim,Vilgelmi Inna,Bakarev Maksim,Maiborodina Vitalina

Abstract

The scientific literature of recent years contains a lot of data about using multipotent stromal cells (MSCs) for urinary incontinence correction. Despite this, the ideal treatment method for urinary incontinence has not yet been created. The cell therapy results in patients and experimental animals with incontinence have shown promising results, but the procedures require further optimization, and more research is needed to focus on the clinical phase. The MSC use appears to be a feasible, safe, and effective method of treatment for patients with urinary incontinence. However, the best mode for application of cell technology is still under study. Most clinical investigations have been performed on only a few patients and during rather short follow-up periods, which, together with an incomplete knowledge of the mechanisms of MSC action, does not make it possible for their widespread implementation. The technical details regarding the MSC application remain to be identified in more rigorous preclinical and clinical trials.

Publisher

MDPI AG

Subject

General Biochemistry, Genetics and Molecular Biology,Medicine (miscellaneous)

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