Author:
Cao Mengjiao,Liu Chengcheng,Li Mengxin,Zhang Xu,Peng Li,Liu Lijia,Liao Jinfeng,Yang Jing
Abstract
The repair of infected bone defects (IBDs) is still a great challenge in clinic. A successful treatment for IBDs should simultaneously resolve both infection control and bone defect repair. Hydrogels are water-swollen hydrophilic materials that maintain a distinct three-dimensional structure, helping load various antibacterial drugs and biomolecules. Hybrid hydrogels may potentially possess antibacterial ability and osteogenic activity. This review summarizes the recent progress of different kinds of antibacterial agents (including inorganic, organic, and natural) encapsulated in hydrogels. Several representative hydrogels of each category and their antibacterial mechanism and effect on bone repair are presented. Moreover, the advantages and disadvantages of antibacterial agent hybrid hydrogels are discussed. The challenge and future research directions are further prospected.
Funder
the National Natural Science Foundation
Subject
Polymers and Plastics,Organic Chemistry,Biomaterials,Bioengineering
Cited by
3 articles.
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