The Discovery of Cyclic Lipopeptide Olenamidonins in a Deepsea-Derived Streptomyces Strain by Knocking Out a DtxR Family Regulator-Reference-Cited by-同舟云学术

The Discovery of Cyclic Lipopeptide Olenamidonins in a Deepsea-Derived Streptomyces Strain by Knocking Out a DtxR Family Regulator

Published:2024-06-06 Issue:6 Volume:22 Page:262
ISSN:1660-3397
Container-title:Marine Drugs
language:en
Short-container-title:Marine Drugs

Author:

Sun Qiannan¹,Yu Dongqi¹,Zhang Xueqing¹,Xiao Fei¹,Li Wenli¹²³^ORCID

Affiliation:

1. Key Laboratory of Marine Drugs, Ministry of Education of China, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266071, China

2. Laboratory for Marine Drugs and Bioproducts, Qingdao National Laboratory for Marine Science and Technology, Qingdao 266000, China

3. College of Chemistry & Pharmacy, Northwest A&F University, Yangling 712100, China

Abstract

Three new cyclic lipopeptides, olenamidonins A-C (1–3), in addition to two previously reported metabolites (4 and 5), were accumulated in the ΔdtxRso deletion mutant of deepsea-derived Streptomyces olivaceus SCSIO 1071. The structures of these cyclic lipopeptides were determined by a combination of spectroscopic methods and circular dichroism (CD) measurement. The antibacterial assay results showed that compounds 1–5 displayed different degrees of growth inhibition against multidrug-resistant (MDR) bacterial strains Enterococcus faecalis CCARM 5172 and Enterococcus faecium CCARM 5203 with minimum inhibitory concentrations (MICs) of 1.56−6.25 μg/mL.

Funder

Shandong Provincial Natural Science Foundation

National Natural Science Foundation of China

Fundamental Research Funds for the Central Universities

Publisher

MDPI AG

Link

https://www.mdpi.com/1660-3397/22/6/262/pdf

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