Facile Synthesis and X-ray Attenuation Properties of Ultrasmall Platinum Nanoparticles Grafted with Three Types of Hydrophilic Polymers-Reference-Cited by-同舟云学术

Facile Synthesis and X-ray Attenuation Properties of Ultrasmall Platinum Nanoparticles Grafted with Three Types of Hydrophilic Polymers

Published:2023-02-22 Issue:5 Volume:13 Page:806
ISSN:2079-4991
Container-title:Nanomaterials
language:en
Short-container-title:Nanomaterials

Author:

Saidi Abdullah Khamis Ali Al¹^ORCID,Ghazanfari Adibehalsadat¹,Liu Shuwen¹,Tegafaw Tirusew¹^ORCID,Ahmad Mohammad Yaseen¹^ORCID,Zhao Dejun¹,Liu Ying¹,Yang So Hyeon²^ORCID,Hwang Dong Wook²^ORCID,Yang Ji-ung³,Park Ji Ae³^ORCID,Jung Jae Chang⁴,Nam Sung-Wook⁵^ORCID,Chang Yongmin⁵,Lee Gang Ho¹^ORCID

Affiliation:

1. Department of Chemistry, College of Natural Sciences, Kyungpook National University, Taegu 41566, Republic of Korea

2. Department of Medical & Biological Engineering, Kyungpook National University, Taegu 41944, Republic of Korea

3. Division of RI-Convergence Research, Korea Institute of Radiological & Medical Science, Seoul 01817, Republic of Korea

4. Department of Biology, College of Natural Sciences, Kyungpook National University, Taegu 41566, Republic of Korea

5. Department of Molecular Medicine, School of Medicine, Kyungpook National University, Taegu 41944, Republic of Korea

Abstract

Ultrasmall platinum nanoparticles (Pt-NPs) grafted with three types of hydrophilic and biocompatible polymers, i.e., poly(acrylic acid), poly(acrylic acid-co-maleic acid), and poly(methyl vinyl ether-alt-maleic acid) were synthesized using a one-pot polyol method. Their physicochemical and X-ray attenuation properties were characterized. All polymer-coated Pt-NPs had an average particle diameter (davg) of 2.0 nm. Polymers grafted onto Pt-NP surfaces exhibited excellent colloidal stability (i.e., no precipitation after synthesis for >1.5 years) and low cellular toxicity. The X-ray attenuation power of the polymer-coated Pt-NPs in aqueous media was stronger than that of the commercial iodine contrast agent Ultravist at the same atomic concentration and considerably stronger at the same number density, confirming their potential as computed tomography contrast agents.

Funder

National Research Foundation

Publisher

MDPI AG

Subject

General Materials Science,General Chemical Engineering

Link

https://www.mdpi.com/2079-4991/13/5/806/pdf

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