Long-Term Spasticity Management in Post-Stroke Patients: Issues and Possible Actions—A Systematic Review with an Italian Expert Opinion

Author:

Morone Giovanni12ORCID,Baricich Alessio3ORCID,Paolucci Stefano4,Bentivoglio Anna Rita5,De Blasiis Paolo6,Carlucci Matilde7,Violi Francesco8,Levato Gabriella9,Pani Marcello10,Carpagnano Lucia Federica11,Spandonaro Federico1213ORCID,Picelli Alessandro1415ORCID,Smania Nicola14ORCID

Affiliation:

1. Department of Life, Health and Environmental Sciences, University of L’Aquila, 67100 L’Aquila, Italy

2. San Raffaele Institute of Sulmona, 67039 Sulmona, Italy

3. Physical Medicine and Rehabilitation, Department of Health Sciences, Università del Piemonte Orientale, 28100 Novara, Italy

4. Santa Lucia Foundation, IRCCS, 00179 Rome, Italy

5. Neuroscience Department, Policlinico Universitario Agostino Gemelli, IRCCS, 00168 Roma, Italy

6. Department of Mental and Physical Health and Preventive Medicine, Section of Human Anatomy, University of Campania “Luigi Vanvitelli”, 80138 Naples, Italy

7. Healthcare Directorate, AOUI Verona, 37126 Verona, Italy

8. Internal Medicine Department, Sapienza Università di, 00185 Roma, Italy

9. Health Protection Agency of Milan, 20122 Milan, Italy

10. Policlinico Universitario Agostino Gemelli, IRCCS, 00168 Roma, Italy

11. Hospital Medical Management Department, AOUI, 37126 Verona, Italy

12. C.R.E.A. Sanità, University San Raffaele, 00166 Rome, Italy

13. C.R.E.A. Sanità (Centre for Applied Economic Research in Healthcare), 00196 Rome, Italy

14. Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, 37134 Verona, Italy

15. Canadian Advances in Neuro-Orthopaedics for Spasticity Congress (CANOSC), Kingston, ON K7K 1Z6, Canada

Abstract

Spasticity is a well-known motor dysfunction occurring after a stroke. A group of Italian physicians’ experts in treating post-stroke spasticity (PSS) reviewed the current scientific evidence concerning the state-of-the-art clinical management of PSS management and the appropriate use of botulinum toxin, aiming to identify issues, possible actions, and effective management of the patient affected by spasticity. The participants were clinicians specifically selected to cover the range of multidisciplinary clinical and research expertise needed to diagnose and manage PSS. When evidence was not available, the panel discussed and agreed on the best way to manage and treat PSS. To address the barriers identified, the panel provides a series of consensus recommendations. This systematic review provides a focused guide in the evaluation and management of patients with PSS and its complications. The recommendations reached by this panel of experts should be used by less-experienced doctors in real life and should be used as a guide on how to best use botulinum toxin injection in treating spasticity after a stroke.

Funder

Ipsen

Publisher

MDPI AG

Subject

Health Information Management,Health Informatics,Health Policy,Leadership and Management

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