Gordonia sputi as an Arising Causative Agent of Bacteremia in Immunocompromised Comorbid Dialysis Patients—A Case Report

Author:

Vergov Bozhidar12,Angelova Andreana345,Baldzhieva Alexandra356ORCID,Kalchev Yordan345,Tsochev Georgi2,Murdjeva Marianna3456

Affiliation:

1. Department of Medical Biology, Faculty of Medicine, Medical University of Plovdiv, 4000 Plovdiv, Bulgaria

2. Department of Dialysis Treatment, St George University Hospital, 6000 Plovdiv, Bulgaria

3. Department of Medical Microbiology and Immunology “Prof. Dr. Elissay Yanev”, Faculty of Pharmacy, Medical University of Plovdiv, 4000 Plovdiv, Bulgaria

4. Laboratory of Microbiology, St George University Hospital, 6000 Plovdiv, Bulgaria

5. Research Institute at Medical University of Plovdiv, 4000 Plovdiv, Bulgaria

6. Laboratory of Clinical Immunology, St George University Hospital, 6000 Plovdiv, Bulgaria

Abstract

Improvements in medical care have turned severe diseases into chronic conditions, but often their treatment and the use of medical devices are related to specific complications. Here, we present a clinical case of a long-term dialysis patient who was infected with a rare opportunistic infectious agent—Gordonia sputi. In recent years, the incidence of Gordonia spp. infections in immunocompromised patients with central venous catheters (CVC) has appeared to rise. The isolation and identification of Gordonia spp. are challenging and require modern techniques. In addition, the treatment is usually persistent and often results in CVC extraction, which is associated with further risk and costs for the patient. We also studied the alterations in the immune status of the patient caused by long-term renal replacement therapy and persistent hepatitis C virus infection. Antibiotic therapy and immunostimulation with Inosine pranobex lead to successful eradication of the infection without the need for CVC replacement.

Funder

National University Complex for Biomedical and Translational Research

Publisher

MDPI AG

Subject

Health Information Management,Health Informatics,Health Policy,Leadership and Management

Reference43 articles.

1. IL-10, IL-6, and TNF-α: Central factors in the altered cytokine network of uremia—The good, the bad, and the ugly;Stenvinkel;Kidney Int.,2005

2. Mortality in dialysis patients: Analysis of the causes of death;Mailloux;Am. J. Kidney Dis.,1991

3. (2023, July 08). Annual Data Report|USRDS, Available online: https://usrds-adr.niddk.nih.gov/2022/end-stage-renal-disease/6-mortality.

4. Prediction of all-cause mortality in haemodialysis patients using a Bayesian network;Siga;Nephrol. Dial. Transplant.,2020

5. Proposal of a New Genus, Gordona, for Slightly Acid-fast Organisms Occurring in Sputa of Patients with Pulmonary Disease and in Soil;Tsukamura;J. Gen. Microbiol.,1971

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