The Role of Systemic Oxidative Status in Coronary Arterial and Peripheral Venous Blood of Patients with Unstable Angina Pectoris

Author:

Dragan Panic D.1,Ivan Simic B.2,Goran Davidovic Z.2,Maja Nikolic D.3,Nevena Lazarevic D.45ORCID,Marijana Andjic M.4,Jelena Vuckovic M.26,Nenad Zornic J.7,Vladimir Zivkovic I.358,Turnic Tamara Nikolic489ORCID,Vladimir Jakovljevic Lj3810ORCID,Violeta Iric Cupic M.2

Affiliation:

1. Department of Cardiology, General Hospital Cuprija, Miodraga Novakovic 78, 35230 Cuprija, Serbia

2. Department of Internal Medicine, Faculty of Medical Sciences, University of Kragujevac, Svetozara Markovica 69, 34000 Kragujevac, Serbia

3. Department of Physiology, Faculty of Medical Sciences, University of Kragujevac, Svetozara Markovica 69, 34000 Kragujevac, Serbia

4. Department of Pharmacy, Faculty of Medical Sciences, University of Kragujevac, Svetozara Markovica 69, 34000 Kragujevac, Serbia

5. Department of Clinical Pharmacology, I.M. Sechenov First Moscow State Medical University (Sechenov University), 119435 Moscow, Russia

6. Department of Cardiology, University Clinical Center Kragujevac, Zmaj Jovina 30, 34000 Kragujevac, Serbia

7. Department of Surgery, Faculty of Medical Sciences, University of Kragujevac, Svetozara Markovica 69, 34000 Kragujevac, Serbia

8. Center of Excellence for Redox Balance Research in Cardiovascular and Metabolic Disorders, Medical University (Sechenov University), 34000 Kragujevac, Serbia

9. N.A. Semashko Public Health and Healthcare Department, F.F. Erismann Institute of Public Health, I.M. Sechenov First Moscow State Medical University (Sechenov University), 119991 Moscow, Russia

10. Department of Human Pathology, University I.M. Sechenov, 1st Moscow State Medical, Trubetskaya Street 8, Str. 2, 119991 Moscow, Russia

Abstract

(1) Background: We aimed to analyze the oxidative status of patients with unstable angina pectoris (UA), as well as to determine the correlation of these parameters between coronary arterial and peripheral venous blood samples. (2) Methods: The study included 47 human subjects with UA and 45 control subjects. We performed clinical examinations, hemodynamic and coronary angiography measures. Also, in the blood samples, we measured routine laboratory markers and the concentration of pro-oxidants: index of lipid peroxidation (TBARS), superoxide anion radical (O2−), hydrogen peroxide (H2O2) and nitrites (NO2−), while antioxidant parameters were determined from red blood cells: reduced glutathione (GSH), catalase (CAT) and superoxide dismutase (SOD). All parameters were determined spectrophotometrically. (3) Results: Significantly higher values of TBARS and all measured antioxidants SOD, CAT and GSH were observed in the coronary arterial blood of the UA group relative to coronary arterial blood of the control subjects. On the other hand, in the peripheral venous blood samples, a significantly lower GSH value was found in the UA group compared to the control. (4) Conclusions: This study has shown that the majority of changes in all measured redox markers are found in coronary blood, especially related to the activity of antioxidant components. In patients with an unstable form of angina, prooxidants (superoxide anion radical and index of lipid peroxidation) and endogenous antioxidants (catalase, superoxide dismutase and reduced glutathione) are in direct correlation with the course of ischemic disease. Future studies, where participants would be randomized depending on symptom duration, are necessary to confirm these conclusions.

Funder

Faculty of Medical Sciences, University of Kragujevac, Serbia and Junior Project

Publisher

MDPI AG

Subject

Paleontology,Space and Planetary Science,General Biochemistry, Genetics and Molecular Biology,Ecology, Evolution, Behavior and Systematics

Reference49 articles.

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3. Gracia, K.S., Llanas-Cornejo, D., and Husi, H. (2017). CVD and Oxidative Stress. J. Clin. Med., 6.

4. Senoner, T., and Dichtl, W. (2019). Review Oxidative Stress in Cardiovascular Diseases: Still a Therapeutic Target?. Nutrients, 11.

5. Đukić, M. (2008). Oksidativni Stres: Kliničko-Dijagnostički Značaj, Vulkan izdavaštvo.

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