A Multi-Pathogen Retrospective Study in Patients Hospitalized for Acute Gastroenteritis

Author:

Zizza Antonella1ORCID,Guido Marcello2ORCID,Sedile Raffaella1,Benelli Marzia3,Nuzzo Milva4,Paladini Pasquale3,Romano Anacleto4,Grima Pierfrancesco4ORCID

Affiliation:

1. Institute of Clinical Physiology, National Research Council, 73100 Lecce, Italy

2. Laboratory of Hygiene, Department of Biological and Environmental Sciences and Technologies, University of Salento, 73100 Lecce, Italy

3. Pediatric Unit, Vito Fazzi Hospital, 73100 Lecce, Italy

4. Infectious Diseases Unit, Vito Fazzi Hospital, 73100 Lecce, Italy

Abstract

Acute gastroenteritis (AGE) is a gastrointestinal tract disease often caused by consuming food or water contaminated by bacteria, viruses, or parasites, that can lead to severe symptoms requiring hospitalization. A retrospective study on patients admitted for AGE between 2021 and 2023 at the Pediatrics and Infectious Diseases Departments of Lecce Hospital was conducted. Demographic characteristics, year and month of admission, length of hospital stay, etiological agents, co-infections, and blood chemistry data of patients were collected. The study included 103 patients ranging in age from 0 to 15 years, with 58.25% being male. A total of 78 bacterial, 35 viral, and 7 parasitic infections were identified. The most commonly detected pathogens were Escherichia coli (38.83%), Norovirus (28.16%), Campylobacter jejuni (22.33%), and Salmonella typhi/paratyphi (10.68%). Only a few cases of Cryptosporidium (5.83%) were identified. Additionally, 17 co-infections (16.50%) were detected. Viral infections are the primary cause of hospitalization for AGE in children <5 years, while bacterial infections are more common among older patients. The significantly higher number of children <5 years old with elevated creatinine compared to children ≥5 years suggested that young children are more susceptible to dehydration than older children. Few cases of AGE were attributed to pathogens for which a vaccine has already been licensed. AGE is a serious health concern that could be effectively prevented by implementing food-based and community-level sanitation systems, as well as by increasing vaccination coverage of available vaccines and developing new effective and safe vaccines.

Publisher

MDPI AG

Reference65 articles.

1. GBD 2019 Diseases and Injuries Collaborators (2020). Global burden of 369 diseases and injuries in 204 countries and territories, 1990–2019: A systematic analysis for the Global Burden of Disease Study 2019. Lancet, 396, 1204–1222.

2. The health and economic impact of acute gastroenteritis in Belgium, 2010–2014;Papadopoulos;Epidemiol. Infect.,2019

3. Barker, S.F., Zomer, E., O’Toole, J., Sinclair, M., Gibney, K., Liew, D., and Leder, K. (2018). Cost of gastroenteritis in Australia: A healthcare perspective. PLoS ONE, 13.

4. GBD 2016 Diarrhoeal Disease Collaborators (2018). Estimates of the global, regional, and national morbidity, mortality, and aetiologies of diarrhoea in 195 countries: A systematic analysis for the global burden of disease study 2016. Lancet Infect. Dis., 18, 1211–1228.

5. Incidence, Etiology, and Healthcare Utilization for Acute Gastroenteritis in the Community, United States;Schmidt;Emerg. Infect. Dis.,2022

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3