Neuroprotective Effect of Resveratrol against Manganese-Induced Oxidative Stress and Matrix Metalloproteinase-9 in an “In Vivo” Model of Neurotoxicity

Author:

Latronico Tiziana1ORCID,Rossano Rocco2ORCID,Miniero Daniela Valeria1ORCID,Casalino Elisabetta3ORCID,Liuzzi Grazia Maria1ORCID

Affiliation:

1. Department of Biosciences, Biotechnologies and Environment, University of Bari “A. Moro”, 70126 Bari, Italy

2. Department of Sciences, University of Basilicata, 85100 Potenza, Italy

3. Department of Veterinary Medicine, University of Bari “A. Moro”, 70010 Bari, Italy

Abstract

Chronic exposure to manganese (Mn) leads to its accumulation in the central nervous system (CNS) and neurotoxicity with not well-known mechanisms. We investigated the involvement of matrix metalloproteinase (MMP)-2 and -9 in Mn neurotoxicity in an in vivo model of rats treated through an intraperitoneal injection, for 4 weeks, with 50 mg/kg of MnCl2 in the presence or in the absence of 30 mg/kg of resveratrol (RSV). A loss of weight was observed in Mn-treated rats compared with untreated and RSV-treated rats. A progressive recovery of body weight was detected in rats co-treated with Mn and RSV. The analysis of brain homogenates indicated that RSV counteracted the Mn-induced increase in MMP-9 levels and reactive oxygen species production as well as the Mn-induced decrease in superoxide dismutase activity and glutathione content. In conclusion, Mn exposure, resulting in MMP-9 induction with mechanisms related to oxidative stress, represents a risk factor for the development of CNS diseases.

Publisher

MDPI AG

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