Evolution of an Extended Pathogenicity Motif in VP2 of Infectious Pancreatic Necrosis Virus Isolates from Farmed Rainbow Trout in Turkey-Reference-Cited by-同舟云学术

Evolution of an Extended Pathogenicity Motif in VP2 of Infectious Pancreatic Necrosis Virus Isolates from Farmed Rainbow Trout in Turkey

Published:2024-06-20 Issue:6 Volume:16 Page:994
ISSN:1999-4915
Container-title:Viruses
language:en
Short-container-title:Viruses

Author:

Tamer Cuneyt¹^ORCID,Ulrich Kristina²^ORCID,Di Paola Nicholas³,Kurucay Hanne Nur¹^ORCID,Albayrak Harun¹^ORCID,Weidmann Manfred⁴^ORCID

Affiliation:

1. Department of Virology, Faculty of Veterinary Medicine, Ondokuz Mayıs University, 55139 Samsun, Turkey

2. Institute of Aquaculture, University of Stirling, Scotland FK9 4LA, UK

3. Center for Genome Sciences, US Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD 21702-5011, USA

4. Medizinische Hochschule Brandenburg Theodor Fontane, 01968 Senftenberg, Germany

Abstract

Infectious pancreatic necrosis virus (IPNV) causes economic losses with a highly variable mortality rate worldwide, especially in rainbow trout. The virus has a double-stranded bi-partite RNA genome designated segment A and B. New complete genome sequences of nine rainbow trout isolates from Turkey were determined and subjected to phylogenetic analysis, identifying all as genotype 5 (serotype Sp). A time-dependent change in the extended pathogenicity motif of VP2 from P217T221A247 (PTA) to PTE P217T221E247 over a period of 10 years was identified. A wider analysis of 99 IPNV sequences from Turkey and Iran revealed the emergence of the motif PTE from 2007 to 2017, inducing significant morbidity in fry by 2013. In fact, displacement of the PTA motif, by the PTE motif in IPNV isolates appeared to be connected to a production peak of rainbow trout in 2013. An additional CAI analysis provided more evidence, indicating that rainbow trout culture in Turkey has an influence on the evolution of IPNV.

Publisher

MDPI AG

Link

https://www.mdpi.com/1999-4915/16/6/994/pdf

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