Alterations of the Fatty Acid Profile and the Expression of Genes Related to FA Metabolism in Cirrhotic Liver Tissue-Reference-Cited by-同舟云学术

Alterations of the Fatty Acid Profile and the Expression of Genes Related to FA Metabolism in Cirrhotic Liver Tissue

Published:2024-07-25 Issue:15 Volume:25 Page:8115
ISSN:1422-0067
Container-title:International Journal of Molecular Sciences
language:en
Short-container-title:IJMS

Author:

Hliwa Aleksandra¹^ORCID,Lange-Andrzejewska Oliwia²^ORCID,Laski Dariusz³,Sledzinski Maciej³^ORCID,Remiszewski Piotr³,Drobinska Anna⁴,Mika Adriana¹²^ORCID,Sledzinski Tomasz¹^ORCID

Affiliation:

1. Department of Pharmaceutical Biochemistry, Faculty of Pharmacy, Medical University of Gdansk, Debinki 1, 80-211 Gdansk, Poland

2. Department of Environmental Analytics, Faculty of Chemistry, University of Gdansk, Wita Stwosza 63, 80-308 Gdansk, Poland

3. Department of General, Endocrine and Transplant Surgery, Faculty of Medicine, Medical University of Gdansk, Smoluchowskiego 17, 80-214 Gdansk, Poland

4. Department of Paediatrics, Nephrology and Hypertension, Faculty of Medicine, Medical University of Gdansk, Smoluchowskiego 17, 80-214 Gdansk, Poland

Abstract

In addition to direct damage to hepatocytes, long-term ethanol consumption leads to lipid accumulation and hepatic steatosis, as well as to the dysregulation of lipid metabolism. The final step in various liver diseases is cirrhosis. The aim of this study was to compare the FA (fatty acids) profile and expression levels of genes involved in lipid metabolism in cirrhotic liver tissue and normal liver tissue. Exploring the changes in the FA profile and expression of genes related to fatty acid metabolism in cirrhotic liver tissue reveals a molecular landscape that goes beyond the surface of traditional liver function assessments. Understanding the shifts in gene expression and fatty acid composition in liver tissue opens avenues for interventions that may aid in the treatment of cirrhosis in the future.

Funder

Medical University of Gdansk

Young Creator of Science–II edition

Publisher

MDPI AG

Link

https://www.mdpi.com/1422-0067/25/15/8115/pdf

Reference39 articles.

1. Liver cirrhosis;Krag;Lancet,2021

2. ACG Clinical Guideline: Alcoholic Liver Disease;Singal;Am. J. Gastroenterol.,2018

3. Liu, S.Y., Tsai, I.T., and Hsu, Y.C. (2021). Alcohol-related liver disease: Basic mechanisms and clinical perspectives. Int. J. Mol. Sci., 22.

4. Pathogenic mechanisms and regulatory factors involved in alcoholic liver disease;Yan;J. Transl. Med.,2023

5. Hliwa, A., Ramos-Molina, B., Laski, D., Mika, A., and Sledzinski, T. (2021). The role of fatty acids in non-alcoholic fatty liver disease progression: An update. Int. J. Mol. Sci., 22.