Affiliation:
1. AB Biotek Human Nutrition and Health, 08017 Barcelona, Spain
Abstract
Diarrhoea is a serious cause of mortality worldwide that can lead to dehydration, gut barrier function impairment, nutrient malabsorption, and alterations of the gut microbiota (dysbiosis). The current solutions for its management, such as oral rehydration salts (ORS), inhibitors of gut motility, antibiotics, and living probiotics, only partially counteract the mechanisms of the disease and do not provide a full coverage of the problem. The potential risks of the use of living probiotic strains, particularly in immunocompromised patients, can be eliminated with the use of tyndallized (heat-killed) postbiotic bacteria and yeast. ABB C22® is a postbiotic combination of three tyndallized yeasts, namely Saccharomyces boulardii, Saccharomyces cerevisiae, and Kluyveromyces marxianus. To assess the action of the postbiotic combination on diarrhoea, immune and gut epithelial cell signalling assays, the gut barrier formation assay, and the rotavirus gene expression assay were performed. ABB C22® showed a strong anti-inflammatory effect, an induction of the build-up of the gut epithelium, and a degree of protection against rotavirus infection. These experimental studies support the use of the postbiotic ABB C22® as a solution for the management of diarrhoea and gastrointestinal conditions, alone or in combination with existing but incomplete treatments.
Reference43 articles.
1. World Health Organization (WHO) (2021, September 10). Diarrhoeal Disease. Key Facts. Available online: https://www.who.int/news-room/fact-sheets/detail/diarrhoeal-disease.
2. CDC (2021, September 10). Centers for Disease Control and Prevention. U.S. Department of Health and Human Services. Diarrhea: Common Illness, Global Killer, Available online: https://www.cdc.gov/healthywater/pdf/global/programs/global-diarrhea508c.pdf.
3. Rotavirus and severe childhood diarrhea;Parashar;Emerg. Infect. Dis.,2006
4. Chronic diarrhoea in children: A practical algorithm-based approach;Shankar;J. Paediatr. Child. Health,2020
5. Prolonged episodes of acute diarrhea reduce growth and increase risk of persistent diarrhea in children;Moore;Gastroenterology,2010