Metabolic Risk in Patients with a Diminished Ovarian Reserve and Premature Ovarian Insufficiency

Author:

Robeva Ralitsa1ORCID,Elenkova Atanaska1,Kirilov Georgi1,Zacharieva Sabina1

Affiliation:

1. Department of Endocrinology, Faculty of Medicine, Medical University—Sofia, USHATE “Acad. Iv. Penchev”, 2, Zdrave Str., 1431 Sofia, Bulgaria

Abstract

Objective: Diminished ovarian reserve (DOR) and premature ovarian insufficiency (POI) represent conditions of different severity, characterized by an earlier-than-expected decrease in ovarian activity. The present study aims to compare metabolic disturbances between women with DOR and patients with POI from a different origin. Materials and methods: A total of 226 women (28 healthy women; 77 individuals with DOR, and 121 patients with POI/36 with Turner syndrome [TS] and 85 with non-TS POI/) have been studied retrospectively. Data concerning anthropometric indices, and metabolic parameters were collected. Results: Patients with DOR, non-TS POI, and TS had increased blood pressure and liver enzymes, pronounced insulin resistance, and worse lipid profiles than controls (p < 0.008 for all). TS patients had significantly higher ASAT, GGT, and TSH levels compared to non-TS POI and DOR individuals. The prevalence of type 2 diabetes tended to be higher in TS women compared to other groups. The prevalence of previously diagnosed polycystic ovarian syndrome was lower in the non-TS POI patients than in the DOR patients (p = 0.005). Conclusions: patients with decreased ovarian function suffer from insulin resistance, abnormal lipid profile, and subtle hepatic disturbances, irrespective of the severity of the condition and the presence of chromosomal aberrations.

Funder

STRATEGIC RESEARCH AND INNOVATION PROGRAMME FOR DEVELOPMENT OF MEDICAL UNIVERSITY—SOFIA

European Union

Publisher

MDPI AG

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