Abstract
It is well-known that serum and cellular concentrations of zinc are altered in breast cancer patients. Specifically, there are notable zinc hyper-aggregates in breast tumor cells when compared to normal mammary epithelial cells. However, the mechanisms responsible for zinc accumulation and the consequences of zinc dysregulation are poorly understood. In this review, we detailed cellular zinc regulation/dysregulation under the influence of varying levels of sex steroids and breast cancer tumorigenesis to try to better understand the intricate relationship between these factors based on our current understanding of the CmPn/CmP signaling network. We also made some efforts to propose a relationship between zinc signaling and the CmPn/CmP signaling network.
Subject
Molecular Biology,Biochemistry
Reference138 articles.
1. Descriptive analysis of estrogen receptor (ER)-negative, progesterone receptor (PR)-negative, and HER2-negative invasive breast cancer, the so-called triple-negative phenotype: A population-based study from the California cancer Registry;Cancer,2007
2. Breast cancer epidemiology in blacks and whites: Disparities in incidence, mortality, survival rates and histology;J. Natl. Med. Assoc.,2008
3. Venturelli, S., Leischner, C., Helling, T., Renner, O., Burkard, M., and Marongiu, L. (2022). Minerals and Cancer: Overview of the Possible Diagnostic Value. Cancers, 14.
4. Overview of resistance to systemic therapy in patients with breast cancer;Adv. Exp. Med. Biol.,2007
5. Annual Report to the Nation on the Status of Cancer, 1975–2011, Featuring Incidence of Breast Cancer Subtypes by Race/Ethnicity, Poverty, and State;J. Natl. Cancer Inst.,2015
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