The Association of Four Natural Molecules—EGCG, Folic Acid, Vitamin B12, and HA—To Counteract HPV Cervical Lesions: A Case Report

Author:

Grandi Giovanni1ORCID,Botticelli Laura2,Fraia Pietro Di3,Babalini Carla3,Masini Meris1,Unfer Vittorio4

Affiliation:

1. Department of Medical and Surgical Sciences for Mother, Child and Adult, Obstetrics and Gynecology Unit, University of Modena and Reggio Emilia, Azienda Ospedaliero Universitaria Policlinico, 41125 Modena, Italy

2. Department of Pathology, Azienda Ospedaliero Universitaria Policlinico, University of Modena and Reggio Emilia, 41125 Modena, Italy

3. Di Fraia Laboratori s.r.l., 00034 Colleferro, Italy

4. UniCamillus-Saint Camillus International University of Health Sciences, 00131 Rome, Italy

Abstract

Precancerous lesions of the uterine cervix, due to HPV infections, are still today a great medical challenge. This clinical case highlighted the effectiveness of epigallocatechin gallate (EGCG), vitamin B12, folic acid, and hyaluronic acid (HA) in counteracting HPV lesions in a 39-year-old patient with a long history of viral persistence, cervical lesions of various degree, and several unsuccessful surgical approaches. After eight weeks of treatment, both the histological and cytological analyses revealed only a chronic cervicitis without any malignant lesions or cellular dysplasia, thus reducing the urgency of an invasive surgery, a total hysterectomy.

Publisher

MDPI AG

Subject

Medicine (miscellaneous)

Reference29 articles.

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