Abstract
Antibiotic resistance is a global health challenge that threatens human and animal lives, especially among low-income and vulnerable populations in less-developed countries. Its multi-factorial nature requires integrated studies on antibiotics and resistant bacteria in humans, animals, and the environment. To achieve a comprehensive understanding of the situation and management of antibiotic use and environmental transmission, this paper describes a study protocol to document human exposure to antibiotics from major direct and indirect sources, and its potential health outcomes. Our mixed-methods approach addresses both microbiological and pathogen genomics, and epidemiological, geospatial, anthropological, and sociological aspects. Implemented in two rural residential areas in two provinces in Eastern China, linked sub-studies assess antibiotic exposure in population cohorts through household surveys, medicine diaries, and biological sampling; identify the types and frequencies of antibiotic resistance genes in humans and food-stock animals; quantify the presence of antibiotic residues and antibiotic resistance genes in the aquatic environment, including wastewater; investigate the drivers and behaviours associated with human and livestock antibiotic use; and analyse the national and local policy context, to propose strategies and systematic measurements for optimising and monitoring antibiotic use. As a multidisciplinary collaboration between institutions in the UK and China, this study will provide an in-depth understanding of the influencing factors and allow comprehensive awareness of the complexity of AMR and antibiotic use in rural Eastern China.
Funder
Medical Research Council
National Natural Science Foundation of China
Subject
Health, Toxicology and Mutagenesis,Public Health, Environmental and Occupational Health
Reference25 articles.
1. Origins and Evolution of Antibiotic Resistance
2. The global threat of antimicrobial resistance: science for intervention
3. The antibiotic resistance crisis: Part 1: Cause and threats;Ventola;P T A Peer-Rev. J. Formul. Manag.,2015
4. Global Action Plan on Antimicrobial Resistance 2016
https://www.who.int/publications/i/item/9789241509763
5. Antimicrobial Resistance (Antimicrobial Resistance) [World Health Organization Fact Sheets]
https://www.who.int/news-room/fact-sheets/detail/antimicrobial-resistance
Cited by
8 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献